Evidence map›Paper›PMID 21370369›Full record

ArticleAngewandte Chemie (International ed. in English)2011

The binding of fluorophores to proteins depends on the cellular environment.

Yun Kyung Kim, Jun-Seok Lee, Xuezhi Bi, Hyung-Ho Ha, Shin Hui Ng, Young-hoon Ahn, Jae-Jung Lee, Bridget K Wagner, Paul A Clemons, Young-Tae Chang

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 49 citations in OpenAlex.

  1. Re-Evaluating Hot Mitochondria: Too Slow to Cool.Acta physiologica (Oxford, England) · 2026
    Review
  2. Optimizing multifunctional fluorescent ligands for intracellular labeling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Regulation of mitochondrial temperature in health and disease.Pflugers Archiv : European journal of physiology · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Hot mitochondria?PLoS biology · 2018
    Article
  9. Review
  10. Neural stem cell specific fluorescent chemical probe binding to FABP7.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Yun Kyung KimDepartment of Chemistry, National University of Singapore, Singapore.
Jun-Seok Lee
Xuezhi Bi
Hyung-Ho Ha
Shin Hui Ng
Young-hoon Ahn
Jae-Jung Lee
Bridget K Wagner
Paul A Clemons
Young-Tae Chang
Singapore Bioimaging Consortium · SGBroad Institute · USNational University of Singapore · SGJohns Hopkins University · USKorea Institute of Science and Technology · KR

Funding

Target ID (3 of 4)RL1HG004671 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SCHREIBER, STUART L · 2007 to 2011
$5.8M
Small-molecule fluorophores: "semi-rational design" of librariesP20GM072029 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TING, ALICE Y · 2004 to 2008
$3.0M
NHGRI NIH HHS RL1 HG004671NHGRI NIH HHS RL1-HG004671NIGMS NIH HHS P20 GM072029NIGMS NIH HHS P20-GM072029
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aldehyde DehydrogenaseFluorescent DyesHEK293 CellsHeterocyclic Compounds, 3-RingHumansPiperidinesProtein BindingRNA InterferenceRNA, Small InterferingTubulinAldehyde DehydrogenaseCDy2 compoundFluorescent DyesHeterocyclic Compounds, 3-RingPiperidinesRNA, Small InterferingTubulin

Identifiers

PMID21370369
PMCPMC4758120
OpenAlexW1981037064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.