ArticleInternational journal of clinical pharmacy2011
Dose standardisation of anticancer drugs.
Article in International journal of clinical pharmacy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Excess volume addition method improves human resource efficiency and environmental sustainability of cytotoxic drug preparations.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2025Article
- Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients.Frontiers in pharmacology · 2025Article
- Optimal Dosing Strategy for Fluorescence-Guided Surgery with Panitumumab-IRDye800CW in Head and Neck Cancer.Molecular imaging and biology · 2020Article
- Comparison of toxicity and effectiveness between fixed-dose and body surface area-based dose capecitabine.Therapeutic advances in medical oncology · 2019Article
- The impact of logarithmic dose banding of anticancer drugs on pharmacy compounding efficiency at Ghent University Hospital.European journal of hospital pharmacy : science and practice · 2018Article
- Exploratory analysis for the implementation of antineoplastic logarithmic dose banding.International journal of clinical pharmacy · 2018Article
- Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.European journal of cancer (Oxford, England : 1990) · 2018Article
- Fixed Dosing of Monoclonal Antibodies in Oncology.The oncologist · 2017Review
- Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents.British journal of cancer · 2012Article
- Preparation of intravenous chemotherapy bags: evaluation of a dose banding approach in an Italian oncology hospital.Global & regional health technology assessmentArticle
- Dose-Banding of Intravenous Piperacillin-Tazobactam in Pediatric Surgical Inpatients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective of the studyBody size based dosing is often used for prescribing anticancer drugs. However the scientific and the clinical rationales of this historical method have recently been criticized. As a result, alternative dosing strategies have been suggested, as flat-fixed dosing regimens, but not implemented in routine practice. Dose standardisation is a first step in order to rationalise chemotherapy dose calculation. A new method, derived from dose-banding, was developed, taking into account prescription and economic criteria.
settingFeasibility and interest of this concept were studied in two French cancer centres Institut Curie and Hôpital Saint-Louis.
main outcome measuresThe aim of our study was to assess dose standardisation of expensive anticancer drugs in objectives of quality and economy.
methodNine candidate drugs were selected and standardized rounded doses (SRD) were proposed. To determine the specific standard doses of these two centres, two theoretical and practical methods were applied, and then, their results were compared. For each anticancer drug the objective was to fix SRD in order to cover all the doses most frequently prescribed.
resultsIt has been possible to propose SRD for six of the nine drugs. These SRD have been implemented with the agreement of the medical staff. These doses are, whenever possible, rounded to the nearest vial size, or correspond to a combination of the different strength of the commercial drug.
conclusionOur study shows that dose standardisation is a help to optimise the productivity and improve the organisation of the preparation unit.
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