ArticleJournal of molecular neuroscience : MN2011
Association between DARPP-32 gene polymorphism and personality traits in healthy Chinese-Han subjects.
Article in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Association ofFrontiers in neuroscience · 2022Article
- Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese.Frontiers in psychiatry · 2021Article
- Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction.Advances in pharmacology (San Diego, Calif.) · 2021Review
- Association between GPx-1 polymorphisms and personality traits in healthy Chinese-Han subjects.Brain and behavior · 2020Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Associations Between PPP1R1B Gene Polymorphisms and Anxiety Levels in the Chinese Population.Neuroscience bulletin · 2017Article
- Association between PPP1R1B polymorphisms and defense mechanisms in healthy Chinese-Han subjects.Journal of molecular neuroscience : MN · 2013Article
- Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.Journal of molecular neuroscience : MN · 2012Article
- No association of a casein kinase 1ε (CK1ε) gene polymorphism with personality traits in healthy Chinese-Han subjects.Journal of molecular neuroscience : MN · 2012Article
- Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.Journal of molecular neuroscience : MN · 2012Article
- DARPP-32, Jack of All Trades… Master of Which?Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 32-kDa dopamine- and cAMP-regulated phosphoprotein (DARPP-32) is a key signaling factor in several neurotransmitter pathways (including dopamine and serotonin) that impact personality traits. Therefore, different DARPP-32 alleles may influence the biological determination of distinct personality types. We established an association between the DARPP-32 gene polymorphisms (rs12601930C/T, rs879606A/G, and rs3764352A/G) and personality traits as measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. Of the three polymorphic sites examined, rs12601930C/T was associated with novelty seeking (χ² = 13.06, P = 0.001), while both rs879606A/G and rs3764352A/G were associated with harm avoidance (rs879606: χ² = 7.74, P = 0.021; rs3764352: χ² = 8.53, P = 0.014). There was no significant association between reward dependence scores and DARPP-32 gene polymorphisms. Our results suggest that polymorphisms in the DARPP-32 gene are involved in the biological mechanisms that confer the traits of novelty seeking and harm avoidance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.