ArticleIndian journal of pharmaceutical sciences2008
Microbial production and biomedical applications of lovastatin.
Article in Indian journal of pharmaceutical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 73 citations in OpenAlex.
- A comprehensive review on "bushy bunched" filamentous fungal mycelial hyphae for next-generation surgical sutures - a sustainable approach.Antonie van Leeuwenhoek · 2026Review
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Review
- Exploitation of Sugarcane Bagasse and Environmentally Sustainable Production, Purification, Characterization, and Application of Lovastatin byMolecules (Basel, Switzerland) · 2023Article
- How to Use Statins in Secondary Prevention of Atherosclerotic Diseases: from the Beneficial Early Initiation to the Potentially Unfavorable Discontinuation.Cardiovascular drugs and therapy · 2023Review
- Lipo-Chitooligosaccharides Induce Specialized Fungal Metabolite Profiles That Modulate Bacterial Growth.mSystems · 2022Article
- Preparation ofFood science and biotechnology · 2022Article
- On the Identification and Quantification of Ergothioneine and Lovastatin in Various Mushroom Species: Assets and Challenges of Different Analytical Approaches.Molecules (Basel, Switzerland) · 2021Article
- Quality and Authenticity Control of Functional Red Yeast Rice-A Review.Molecules (Basel, Switzerland) · 2019Review
- Comparative Study on Whole Genome Sequences of Aspergillus terreus (Soil Fungus) and Diaporthe ampelina (Endophytic Fungus) with Reference to Lovastatin Production.Current microbiology · 2018Article
- Optimization of lovastatin production fromJournal, genetic engineering & biotechnology · 2016Article
- Complete Genome Sequence of Soil Fungus Aspergillus terreus (KM017963), a Potent Lovastatin Producer.Genome announcements · 2016Article
- Functional food red yeast rice (RYR) for metabolic syndrome amelioration: a review on pros and cons.World journal of microbiology & biotechnology · 2016Review
- Exploitation of Aspergillus terreus for the Production of Natural Statins.Journal of fungi (Basel, Switzerland) · 2016Review
- Monascus secondary metabolites: production and biological activity.Journal of industrial microbiology & biotechnology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. Lovastatin acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by fermentation decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review deals with the structure, biosynthesis, various modes of fermentation and applications of lovastatin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.