ArticleCellular and molecular bioengineering2009
Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.
Article in Cellular and molecular bioengineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A Game of Life with dormancy.Proceedings. Biological sciences · 2025Article
- Cellular automata modelling of leukaemic stem cell dynamics in acute myeloid leukaemia: insights into predictive outcomes and targeted therapies.Royal Society open science · 2025Article
- Fibre crosslinking drives the emergence of order in a three-dimensional dynamical network model.Royal Society open science · 2024Article
- Bridging the gap between mechanistic biological models and machine learning surrogates.PLoS computational biology · 2023Review
- Data-driven learning how oncogenic gene expression locally alters heterocellular networks.Nature communications · 2022Article
- A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection.PloS one · 2022Article
- Article
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- Shaping the Organ: A Biologist Guide to Quantitative Models of Plant Morphogenesis.Frontiers in plant science · 2021Review
- How and why to build a mathematical model: A case study using prion aggregation.The Journal of biological chemistry · 2020Review
- Homeostasis and systematic ageing as non-equilibrium phase transitions in computational multicellular organizations.Royal Society open science · 2019Article
- A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation.Biomechanics and modeling in mechanobiology · 2019Article
- Metabolic Engineering and Synthetic Biology: Synergies, Future, and Challenges.Frontiers in bioengineering and biotechnology · 2019Article
- Mathematical models of tumor cell proliferation: A review of the literature.Expert review of anticancer therapy · 2018Review
- Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation.Annals of biomedical engineering · 2017Article
- A Six-Stage Workflow for Robust Application of Systems Pharmacology.CPT: pharmacometrics & systems pharmacology · 2016Article
- Theoretical cross-comparative analysis on dynamics of small intestine and colon crypts during cancer initiation.IET systems biology · 2015Article
- A Multiscale Computational Framework to Understand Vascular Adaptation.Journal of computational science · 2015Article
- Article
- Dynamics between cancer cell subpopulations reveals a model coordinating with both hierarchical and stochastic concepts.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Emergent behaviors of multi-cellular biological systems (MCBS) result from the behaviors of each individual cells and their interactions with other cells and with the environment. Modeling MCBS requires incorporating these complex interactions among the individual cells and the environment. Modeling approaches for MCBS can be grouped into two categories: continuum models and cell-based models. Continuum models usually take the form of partial differential equations, and the model equations provide insight into the relationship among the components in the system. Cell-based models simulate each individual cell behavior and interactions among them enabling the observation of the emergent system behavior. This review focuses on the cell-based models of MCBS, and especially, the technical aspect of the rule-based simulation method for MCBS is reviewed. How to implement the cell behaviors and the interactions with other cells and with the environment into the computational domain is discussed. The cell behaviors reviewed in this paper are division, migration, apoptosis/necrosis, and differentiation. The environmental factors such as extracellular matrix, chemicals, microvasculature, and forces are also discussed. Application examples of these cell behaviors and interactions are presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.