ArticleEuropean journal of human genetics : EJHG2011
Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.
Article in European journal of human genetics : EJHG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis.PloS one · 2012Pooled it
- Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.International journal of molecular sciences · 2018Trial
- Gender-specific genetic influence of rs1111875 on diabetes risk: Insights from the Taiwan biobank study.Journal of diabetes investigation · 2025Article
- Sex Differences in the Effects of CDKAL1 Variants on Glycemic Control in Diabetic Patients: Findings from the Korean Genome and Epidemiology Study.Diabetes & metabolism journal · 2022Article
- Genetics of type 2 diabetes mellitus in Indian and Global Population: A Review.The Egyptian journal of medical human genetics · 2022Review
- Toward an Improved Classification of Type 2 Diabetes: Lessons From Research into the Heterogeneity of a Complex Disease.The Journal of clinical endocrinology and metabolism · 2021Review
- Association Between Single Nucleotide Polymorphisms inDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Identification of novel population clusters with different susceptibilities to type 2 diabetes and their impact on the prediction of diabetes.Scientific reports · 2019Article
- Effect of smoking on the association of HHEX (rs5015480) with diabetes among Korean women and heavy smoking men.BMC medical genetics · 2018Article
- Gender differences in the association of ELMO1 genetic variants with type 2 diabetes in Tunisian Arabs.Journal of endocrinological investigation · 2018Article
- Genetic Association Analysis of Fasting and 1- and 2-Hour Glucose Tolerance Test Data Using a Generalized Index of Dissimilarity Measure for the Korean Population.Genomics & informatics · 2016Article
- Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.Journal of Korean medical science · 2015Article
- Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Age- and gender-dependent heterogeneous proportion of variation explained by SNPs in quantitative traits reflecting human health.Age (Dordrecht, Netherlands) · 2015Article
- CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people.Journal of diabetes · 2014Article
- Genome-wide analysis of copy number variations reveals that aging processes influence body fat distribution in Korea Associated Resource (KARE) cohorts.Human genetics · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the genetic associations of previously identified sequence variants with type 2 diabetes mellitus (T2DM) and its potentially genetic heterogeneity by gender in a large-scale cohort. A total of 613 T2DM patients and 8221 control subjects from the Korea Association REsource (KARE) cohort were included in the analysis of genetic association of T2DM with 33 nucleotide polymorphic markers identified by previous studies. The association analysis was further conducted with data partitioned by gender. The association analysis resulted in five nucleotide sequence variants associated with the susceptibility of T2DM after Bonferonni correction (P < 0.0015). One was located near the gene of hematopoietically expressed homeobox (HHEX), and the others were all in the gene of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1). Further analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of T2DM in females (P<0.005), but not in males (P>0.005). We suggested heterogeneous genetic associations of the T2DM susceptibility with the CDKAL1 and HHEX genes by gender.
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