Trial reportGenes and immunity2011
The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax vaccine adsorbed.
Trial report in Genes and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00119067 (Anthrax Vaccine Adsorbed), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anthrax Vaccine Adsorbed: Human Reactogenicity and Immunogenicity Trial to Address Change in Route of Administration and Dose Reduction
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed.Infection and immunity · 2013Trial
- A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.Vaccine · 2012Trial
- Genetic determinants of IgG antibody response to COVID-19 vaccination.American journal of human genetics · 2024Article
- The immunogenetics of COVID-19.Immunogenetics · 2023Review
- Impact of HLA Polymorphism on the Immune Response to Bacillus Anthracis Protective Antigen in Vaccination versus Natural Infection.Vaccines · 2022Article
- Characterization of the UK anthrax vaccine and human immunogenicity.Human vaccines & immunotherapeutics · 2021Article
- Human Leukocyte Antigen (HLA) Alleles Prevent Metabolically-Induced Inflammation and Cerebrocortical Thinning in Gulf War Illness.Journal of neurology & neuromedicine · 2020Article
- Recent developments in the understanding and use of anthrax vaccine adsorbed: achieving more with less.Expert review of vaccines · 2016Review
- An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans.Pharmacology, biochemistry, and behavior · 2015Article
- HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.PLoS pathogens · 2015Article
- Adversomics: a new paradigm for vaccine safety and design.Expert review of vaccines · 2015Review
- NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.Psychopharmacology · 2015Article
- Correlation of HLA-DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection.International journal of clinical and experimental medicine · 2015Article
- Humoral responses to independent vaccinations are correlated in healthy boosted adults.Vaccine · 2014Article
- HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study.Human genetics · 2014Article
- Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.PLoS pathogens · 2014Article
- Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts.Vaccine · 2014Article
- Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.Science translational medicine · 2013Article
- Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations.Vaccine · 2013Article
- Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.Journal of studies on alcohol and drugs · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Host genetic variation, particularly within the human leukocyte antigen (HLA) loci, reportedly mediates heterogeneity in immune response to certain vaccines; however, no large study of genetic determinants of anthrax vaccine response has been described. We searched for associations between the immunoglobulin G antibody to protective antigen (AbPA) response to Anthrax Vaccine Adsorbed (AVA) in humans, and polymorphisms at HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQA1, -DQB1, -DPB1) loci. The study included 794 European-Americans and 200 African-Americans participating in a 43-month, double-blind and placebo-controlled clinical trial of AVA (clinicaltrials.gov identifier NCT00119067). Among European-Americans, genes from tightly linked HLA-DRB1, -DQA1, -DQB1 haplotypes displayed significant overall associations with longitudinal variation in AbPA levels at 4, 8, 26 and 30 weeks from baseline in response to vaccination with three or four doses of AVA (global P=6.53 × 10(-4)). In particular, carriage of the DRB1-DQA1-DQB1 haplotypes (*)1501-(*)0102-(*)0602 (P=1.17 × 10(-5)), (*)0101-(*)0101-(*)0501 (P=0.009) and (*)0102-(*)0101-(*)0501 (P=0.006) was associated with significantly lower AbPA levels. In carriers of two copies of these haplotypes, lower AbPA levels persisted following subsequent vaccinations. No significant associations were observed amongst African-Americans or for any HLA class I allele/haplotype. Further studies will be required to replicate these findings and to explore the role of host genetic variation outside of the HLA region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.