ArticleMolecular biology and evolution2011
Genetic variation in Native Americans, inferred from Latino SNP and resequencing data.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
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- The Simons Genome Diversity Project: A Global Analysis of Mobile Element Diversity.Genome biology and evolution · 2020Article
- Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry.Genome biology and evolution · 2019Article
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- Patterns of Genetic Coding Variation in a Native American Population before and after European Contact.American journal of human genetics · 2018Article
- How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data.Genetics and molecular biology · 2018Article
- Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.Nature communications · 2016Article
- Genomewide ancestry and divergence patterns from low-coverage sequencing data reveal a complex history of admixture in wild baboons.Molecular ecology · 2016Article
- Selection of highly informative SNP markers for population affiliation of major US populations.International journal of legal medicine · 2016Article
- ENGAGING NATIVE AMERICANS IN GENOMICS RESEARCH.American anthropologist · 2015Article
- Sociodemographic and hispanic acculturation factors and isolated anotia/microtia.Birth defects research. Part A, Clinical and molecular teratology · 2014Article
- Patterns of admixture and population structure in native populations of Northwest North America.PLoS genetics · 2014Article
- Effects of sample selection bias on the accuracy of population structure and ancestry inference.G3 (Bethesda, Md.) · 2014Article
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- Imputation-based genomic coverage assessments of current human genotyping arrays.G3 (Bethesda, Md.) · 2013Article
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- Reconstructing Native American population history.Nature · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Analyses of genetic polymorphism data have the potential to be highly informative about the demographic history of Native American populations, but due to a combination of historical and political factors, there are essentially no autosomal sequence polymorphism data from any Native American group. However, there are many resequencing studies involving Latinos, whose genomes contain segments inherited from their Native American ancestors. In this study, we introduce a new method for estimating local ancestry across the genomes of admixed individuals and show how this method, along with dense genotyping and targeted resequencing, can be used to assay genetic variation in ancestral Native American groups. We analyze roughly 6 Mb of resequencing data from 22 Mexican Americans to provide the first large-scale view of sequence level variation in Native Americans. We observe low levels of diversity and high levels of linkage disequilibrium in the Native American-derived sequences, consistent with a recent severe population bottleneck associated with the initial peopling of the Americas. Using two different computational approaches, one novel, we estimate that this bottleneck occurred roughly 12.5 Kya; when uncertainty in the estimation process is taken into account, our results are consistent with archeological estimates for the colonization of the Americas.
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