ArticleProceedings of the National Academy of Sciences of the United States of America2011
Core promoter recognition complex changes accompany liver development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Specificity Proteins (Sp) and Cancer.International journal of molecular sciences · 2023Review
- Gawky modulates MTF-1-mediated transcription activation and metal discrimination.Nucleic acids research · 2021Article
- Site-Specific Phosphorylation of Histone H1.4 Is Associated with Transcription Activation.International journal of molecular sciences · 2020Article
- Embryonic tissue differentiation is characterized by transitions in cell cycle dynamic-associated core promoter regulation.Nucleic acids research · 2020Article
- Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer.Oncotarget · 2017Article
- The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator ofPeerJ · 2017Article
- Targeted alternative splicing of TAF4: a new strategy for cell reprogramming.Scientific reports · 2016Article
- A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation.eLife · 2015Article
- TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.Molecular and cellular biology · 2015Article
- The Mediator complex: a central integrator of transcription.Nature reviews. Molecular cell biology · 2015Review
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- Targeting TBP-Associated Factors in Ovarian Cancer.Frontiers in oncology · 2014Review
- Direct TFIIA-TFIID protein contacts drive budding yeast ribosomal protein gene transcription.The Journal of biological chemistry · 2013Article
- High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.Nature structural & molecular biology · 2013Article
- Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- p53 cooperates with Sp1 to regulate breed-dependent expression of glucocorticoid receptor in the liver of preweaning piglets.PloS one · 2013Article
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- Transcriptional regulation by coactivators in embryonic stem cells.Trends in cell biology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies of several key developmental transitions have brought into question the long held view of the basal transcriptional apparatus as ubiquitous and invariant. In an effort to better understand the role of core promoter recognition and coactivator complex switching in cellular differentiation, we have examined changes in transcription factor IID (TFIID) and cofactor required for Sp1 activation/Mediator during mouse liver development. Here we show that the differentiation of fetal liver progenitors to adult hepatocytes involves a wholesale depletion of canonical cofactor required for Sp1 activation/Mediator and TFIID complexes at both the RNA and protein level, and that this alteration likely involves silencing of transcription factor promoters as well as protein degradation. It will be intriguing for future studies to determine if a novel and as yet unknown core promoter recognition complex takes the place of TFIID in adult hepatocytes and to uncover the mechanisms that down-regulate TFIID during this critical developmental transition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.