ArticleProceedings of the National Academy of Sciences of the United States of America2011
Multiple coregulatory control of tyrosine hydroxylase gene transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Loss of METTL14 in dopaminergic neurons disrupts ER homeostasis via m6A-dependent regulation of Atp2a3 mRNA: Implications for Parkinson's Disease.NPJ Parkinson's disease · 2026Article
- The mCells · 2025Review
- Tyrosine Hydroxylase Inhibitors and Dopamine Receptor Agonists Combination Therapy for Parkinson's Disease.International journal of molecular sciences · 2024Review
- Genetic modifiers of synucleinopathies-lessons from experimental models.Oxford open neuroscience · 2023Review
- Analysis ofBioMed research international · 2023Article
- Article
- Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.Journal of cellular and molecular medicine · 2021Article
- Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats.Analytical cellular pathology (Amsterdam) · 2021Article
- Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence.International journal of molecular sciences · 2019Article
- Conserved Upstream Regulatory Regions in Mammalian Tyrosine Hydroxylase.Molecular neurobiology · 2018Article
- HLA-A2-Restricted Epitopes Identified from MTA1 Could Elicit Antigen-Specific Cytotoxic T Lymphocyte Response.Journal of immunology research · 2018Article
- Signaling coupled epigenomic regulation of gene expression.Oncogene · 2017Review
- Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer.Scientific reports · 2017Article
- Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.The Journal of biological chemistry · 2016Article
- Review
- Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice.PloS one · 2016Article
- Monoamine neurotransmitter disorders--clinical advances and future perspectives.Nature reviews. Neurology · 2015Review
- Physiological functions of MTA family of proteins.Cancer metastasis reviews · 2014Review
- Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging · 2014Article
- Clinical features and pharmacotherapy of childhood monoamine neurotransmitter disorders.Paediatric drugs · 2014Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Despite ubiquitous expression and a high level of metastasis-associated protein 1 (MTA1) coregulator, the physiological role of the MTA1 coactivator remains unknown. We found that MTA1 is a bona fide coactivator and stimulator of tyrosine hydroxylase (TH) transcription in neuronal cells and that MTA1-null mice had lower TH expression in the striatum and substantial nigra. MTA1 physically achieves these functions by interacting directly with DJ1 (Parkinson disease 7) and in turn recruits the DJ1/MTA1/RNA polymerase II complex to the bicoid binding element (BBE) in the TH promoter. Furthermore, we found that the MTA1/DJ1 complex is required for optimum stimulation of the TH expression by paired like homeodomain transcription factor (Pitx3) homeodomain transcription factor and that the MTA1/DJ1 complex is recruited to the TH gene chromatin via the direct interaction of MTA1 with Pitx3. These findings reveal a role for MTA1 as an upstream coactivator of TH and advance the notion of polygenic regulation of a disease-causing gene by coordinated interactions of three regulatory proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.