ArticleProceedings of the National Academy of Sciences of the United States of America2011
Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- The diverse forms and roles of the neuronal endoplasmic reticulum.Nature reviews. Neuroscience · 2026Review
- Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance.Molecular neurobiology · 2023Review
- Ca2+ and cAMP open differentially dilating synaptic fusion pores.Journal of cell science · 2023Article
- ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.PloS one · 2019Article
- Pool size estimations for dense-core vesicles in mammalian CNS neurons.The EMBO journal · 2018Article
- Ryanodine- and CaMKII-dependent release of endogenous CGRP induces an increase in acetylcholine quantal size in neuromuscular junctions of mice.Brain and behavior · 2018Article
- Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Physiological reviews · 2018Review
- Myopic (HD-PTP, PTPN23) selectively regulates synaptic neuropeptide release.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Monoamines differentially modulate neuropeptide release from distinct sites within a single neuron pair.PloS one · 2018Article
- Spike and Neuropeptide-Dependent Mechanisms Control GnRH Neuron Nerve Terminal CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- Polymorphism and division of labour in a socially complex ant: neuromodulation of aggression in the Australian weaver ant, Oecophylla smaragdina.Proceedings. Biological sciences · 2015Article
- Learning modifies odor mixture processing to improve detection of relevant components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy.PloS one · 2015Article
- The effect of stress on motor function in Drosophila.PloS one · 2014Article
- Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Ecto- and endoparasite induce similar chemical and brain neurogenomic responses in the honey bee (Apis mellifera).BMC ecology · 2013Article
- Neuropeptide transmission in brain circuits.Neuron · 2012Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Synaptic release of neurotransmitters is evoked by activity-dependent Ca(2+) entry into the nerve terminal. However, here it is shown that robust synaptic neuropeptide release from Drosophila motoneurons is evoked in the absence of extracellular Ca(2+) by octopamine, the arthropod homolog to norepinephrine. Genetic and pharmacology experiments demonstrate that this surprising peptidergic transmission requires cAMP-dependent protein kinase, with only a minor contribution of exchange protein activated by cAMP (epac). Octopamine-evoked neuropeptide release also requires endoplasmic reticulum Ca(2+) mobilization by the ryanodine receptor and the inositol trisphosphate receptor. Hence, rather than relying exclusively on activity-dependent Ca(2+) entry into the nerve terminal, a behaviorally important neuromodulator uses synergistic cAMP-dependent protein kinase and endoplasmic reticulum Ca(2+) signaling to induce synaptic neuropeptide release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.