ArticleProceedings of the National Academy of Sciences of the United States of America2011
Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed.
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
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- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Layer 5 myelination gates corticothalamic coincidence detection.Nature communications · 2025Article
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Mild focal cooling selectively impacts computations in dendritic trees.bioRxiv : the preprint server for biology · 2024Article
- Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures.Communications biology · 2023Article
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Distinct organization of two cortico-cortical feedback pathways.Nature communications · 2022Article
- Stimulus Feature-Specific Control of Layer 2/3 Subthreshold Whisker Responses by Layer 4 in the Mouse Primary Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei.Frontiers in cellular neuroscience · 2022Article
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- High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.Communications biology · 2021Article
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- Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas.Frontiers in neuroanatomy · 2021Article
- In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration.BMC biology · 2020Article
- Independent representations of self-motion and object location in barrel cortex output.PLoS biology · 2020Article
20 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
The cortical output layer 5 contains two excitatory cell types, slender- and thick-tufted neurons. In rat vibrissal cortex, slender-tufted neurons carry motion and phase information during active whisking, but remain inactive after passive whisker touch. In contrast, thick-tufted neurons reliably increase spiking preferably after passive touch. By reconstructing the 3D patterns of intracortical axon projections from individual slender- and thick-tufted neurons, filled in vivo with biocytin, we were able to identify cell type-specific intracortical circuits that may encode whisker motion and touch. Individual slender-tufted neurons showed elaborate and dense innervation of supragranular layers of large portions of the vibrissal area (total length, 86.8 ± 5.5 mm). During active whisking, these long-range projections may modulate and phase-lock the membrane potential of dendrites in layers 2 and 3 to the whisking cycle. Thick-tufted neurons with soma locations intermingling with those of slender-tufted ones display less dense intracortical axon projections (total length, 31.6 ± 14.3 mm) that are primarily confined to infragranular layers. Based on anatomical reconstructions and previous measurements of spiking, we put forward the hypothesis that thick-tufted neurons in rat vibrissal cortex receive input of whisker motion from slender-tufted neurons onto their apical tuft dendrites and input of whisker touch from thalamic neurons onto their basal dendrites. During tactile-driven behavior, such as object location, near-coincident input from these two pathways may result in increased spiking activity of thick-tufted neurons and thus enhanced signaling to their subcortical targets.
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