ArticleProceedings of the National Academy of Sciences of the United States of America2011
Large-scale mechanical properties of Xenopus embryonic epithelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
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- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.Molecular systems biology · 2026Article
- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.bioRxiv : the preprint server for biology · 2025Article
- Adhesion strength, cell packing density and cell surface buckling in pericellular matrix-mediated tissue cohesion.Development (Cambridge, England) · 2025Article
- Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo.Journal of visualized experiments : JoVE · 2023Article
- Cell cortex regulation by the planar cell polarity protein Prickle1.The Journal of cell biology · 2022Article
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- Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation.Scientific reports · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
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- Cell Sorting in Hydra vulgaris Arises from Differing Capacities for Epithelialization between Cell Types.Current biology : CB · 2020Article
- EpCAM as Modulator of Tissue Plasticity.Cells · 2020Review
- Tissue rheology in embryonic organization.The EMBO journal · 2019Review
- Mechanics of Anteroposterior Axis Formation in Vertebrates.Annual review of cell and developmental biology · 2019Review
- Article
- Multiscale analysis of architecture, cell size and the cell cortex reveals cortical F-actin density and composition are major contributors to mechanical properties during convergent extension.Development (Cambridge, England) · 2018Article
- Physical control of tissue morphogenesis across scales.Current opinion in genetics & development · 2018Review
- Article
- Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle.eLife · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
Epithelia are planar tissues that undergo major morphogenetic movements during development. These movements must work in the context of the mechanical properties of epithelia. Surprisingly little is known about these mechanical properties at the time and length scales of morphogenetic processes. We show that at a time scale of hours, Xenopus gastrula ectodermal epithelium mimics an elastic solid when stretched isometrically; strikingly, its area increases twofold in the embryo by such pseudoelastic expansion. At the same time, the basal side of the epithelium behaves like a liquid and exhibits tissue surface tension that minimizes its exposed area. We measure epithelial stiffness (~1 mN/m), surface tension (~0.6 mJ/m(2)), and epithelium-mesenchyme interfacial tensions and relate these to the folding of isolated epithelia and to the extent of epithelial spreading on various tissues. We propose that pseudoelasticity and tissue surface tension are main determinants of epithelial behavior at the scale of morphogenetic processes.
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