ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 167 citations in OpenAlex.
- Impact of gelatin supplementation on indices of skeletal muscle recovery: a pilot study.European journal of applied physiology · 2026Trial
- Combined effects of photobiomodulation and osteopathic manipulation on the physical performance of young adults subjected to exercise-induced muscle damage: a randomized placebo-controlled trial.Lasers in medical science · 2026Trial
- Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.Histochemistry and cell biology · 2022Trial
- Neuromuscular electrical stimulation and protein during bed rest increases CD11bApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020Trial
- Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men.Nutrients · 2019Trial
- Trial
- Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage.The Journal of physiology · 2017Trial
- Effect of tendon vibration during wide-pulse neuromuscular electrical stimulation (NMES) on the decline and recovery of muscle force.BMC neurology · 2017Trial
- Isokinetic eccentric resistance training prevents loss in mechanical muscle function after running.European journal of applied physiology · 2013Trial
- Morphological adaptation of muscle collagen and receptor of advanced glycation end product (RAGE) in osteoarthritis patients with 12 weeks of resistance training: influence of anti-inflammatory or glucosamine treatment.Rheumatology international · 2013Trial
- Effect of two maximal isometric contractions on eccentric exercise-induced muscle damage of the elbow flexors.European journal of applied physiology · 2013Trial
- Strength training increases the size of the satellite cell pool in type I and II fibres of chronically painful trapezius muscle in females.The Journal of physiology · 2011Trial
- Training and Detraining Effects of Eccentric Exercise and Static Stretching on Hamstring Aponeurosis Dimensions.Scandinavian journal of medicine & science in sports · 2026Article
- Biceps femoris long-head motor unit discharge rates and recruitment thresholds vary across 9 weeks of eccentric training.Journal of sport and health science · 2026Article
- Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026Review
- Muscle or Fascial System Lesion (Part II): The Medial Gastrocnemius and the "Tennis Leg" Paradigm.Cureus · 2025Review
- Hamstring Injury Mechanisms and Eccentric Training-Induced Muscle Adaptations: Current Insights and Future Directions.Sports medicine (Auckland, N.Z.) · 2025Review
- Effect of repeated bout effect induced by eccentric exercises on joint stiffness endurance in males.Physiological reports · 2025Article
- Complementing muscle regeneration-fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle.Nature communications · 2025Article
- Submaximal eccentric resistance training increases serial sarcomere number and improves dynamic muscle performance in old rats.Physiological reports · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to test the hypothesis that remodeling of skeletal muscle extracellular matrix (ECM) is involved in protecting human muscle against injury. Biopsies were obtained from medial gastrocnemius muscles after a single bout of electrical stimulation (B) or a repeated bout (RB) 30 d later, or 30 d after a single stimulation bout (RBc). A muscle biopsy was collected from the control leg for comparison with the stimulated leg. Satellite cell content, tenascin C, and muscle regeneration were assessed by immunohistochemistry; real-time PCR was used to measure mRNA levels of collagens, laminins, heat-shock proteins (HSPs), inflammation, and related growth factors. The large responses of HSPs, CCL2, and tenascin C detected 48 h after a single bout were attenuated in the RB trial, indicative of protection against injury. Satellite cell content and 12 target genes, including IGF-1, were elevated 30 d after a single bout. Among those displaying the greatest difference vs. control muscle, ECM laminin-β1 and collagen types I and III were elevated ∼6- to 9-fold (P<0.001). The findings indicate that the sequenced events of load-induced early deadhesion and later strengthening of skeletal muscle ECM play a role in protecting human muscle against future injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.