ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Submillisecond firing synchrony between different subtypes of cortical interneurons connected chemically but not electrically.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 85 citations in OpenAlex.
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- Heterogeneity of Layer 1 Interneurons in the Mouse Medial Prefrontal Cortex.The Journal of comparative neurology · 2025Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A brief history of somatostatin interneuron taxonomy or: how many somatostatin subtypes are there, really?Frontiers in neural circuits · 2024Review
- Cell-type-specific propagation of visual flicker.Cell reports · 2023Article
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- Excitatory synchronization of rat hippocampal interneurons during network activationFrontiers in cellular neuroscience · 2023Article
- Local connectivity and synaptic dynamics in mouse and human neocortex.Science (New York, N.Y.) · 2022Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality.Current research in neurobiology · 2021Article
- Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons.Frontiers in molecular neuroscience · 2021Article
- Activation of Somatostatin Interneurons by Nicotinic Modulator Lypd6 Enhances Plasticity and Functional Recovery in the Adult Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.eLife · 2020Article
- Phase response theory explains cluster formation in sparsely but strongly connected inhibitory neural networks and effects of jitter due to sparse connectivity.Journal of neurophysiology · 2019Article
- Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits.Trends in neurosciences · 2018Review
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- Distinct Physiological Maturation of Parvalbumin-Positive Neuron Subtypes in Mouse Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Synchronous firing is commonly observed in the brain, but its underlying mechanisms and neurobiological meaning remain debated. Most commonly, synchrony is attributed either to electrical coupling by gap junctions or to shared excitatory inputs. In the cerebral cortex and hippocampus, fast-spiking (FS) or somatostatin-containing (SOM) inhibitory interneurons are electrically coupled to same-type neighbors, and each subtype-specific network tends to fire in synchrony. Electrical coupling across subtypes is weak or absent, but SOM-FS and FS-FS pairs are often connected by inhibitory synapses. Theoretical studies suggest that purely inhibitory coupling can also promote synchrony; however, this has not been confirmed experimentally. We recorded from 74 pairs of electrically noncoupled layer 4 interneurons in mouse somatosensory cortex in vitro, and found that tonically depolarized FS-FS and SOM-FS pairs connected by unidirectional or bidirectional inhibitory synapses often fired within 1 ms of each other. Using a novel, jitter-based measure of synchrony, we found that synchrony correlated with inhibitory coupling strength. Importantly, synchrony was resistant to ionotropic glutamate receptors antagonists but was strongly reduced when GABA(A) receptors were blocked, confirming that in our experimental system IPSPs were both necessary and sufficient for synchrony. Submillisecond firing lags emerged in a computer simulation of pairs of spiking neurons, in which the only assumed interaction between neurons was by inhibitory synapses. We conclude that cortical interneurons are capable of synchronizing both within and across subtypes, and that submillisecond coordination of firing can arise by mutual synaptic inhibition alone, with neither shared inputs nor electrical coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.