ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Brain-generated estradiol drives long-term optimization of auditory coding to enhance the discrimination of communication signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 83 citations in OpenAlex.
- The Influence of Sex, Ear, and Age on Auditory Brainstem Responses Recorded with the NeuroAudio System.Diagnostics (Basel, Switzerland) · 2026Article
- Nongenomic ERα-AMPK Signaling Regulates Sex-Dependent Bcrp Transport Activity at the Blood-Brain Barrier.Endocrinology · 2024Article
- Brain-Generated 17β-Estradiol Modulates Long-Term Synaptic Plasticity in the Primary Auditory Cortex of Adult Male Rats.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Topography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- GPER/GPR30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (Carassius auratus) and colocalizes with isotocin.The Journal of comparative neurology · 2017Article
- Non-ovarian aromatization is required to activate female sexual motivation in testosterone-treated ovariectomized quail.Hormones and behavior · 2016Article
- The dual action of estrogen hypothesis.Trends in neurosciences · 2015Review
- Norepinephrine Modulates Coding of Complex Vocalizations in the Songbird Auditory Cortex Independent of Local Neuroestrogen Synthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- He hears, she hears: are there sex differences in auditory processing?Developmental neurobiology · 2015Article
- Dynamic variation in forebrain estradiol levels during song learning.Developmental neurobiology · 2015Article
- Seasonal plasticity of precise spike timing in the avian auditory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neuroestrogen signaling in the songbird auditory cortex propagates into a sensorimotor network via an 'interface' nucleus.Neuroscience · 2015Article
- Sex differences in the representation of call stimuli in a songbird secondary auditory area.Frontiers in behavioral neuroscience · 2015Article
- Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior.Hormones and behavior · 2014Review
- Relationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain.Hormones and behavior · 2014Article
- Social information embedded in vocalizations induces neurogenomic and behavioral responses.PloS one · 2014Article
- Article
- Inhibition of hippocampal aromatization impairs spatial memory performance in a male songbird.Endocrinology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Auditory processing and hearing-related pathologies are heavily influenced by steroid hormones in a variety of vertebrate species, including humans. The hormone estradiol has been recently shown to directly modulate the gain of central auditory neurons, in real time, by controlling the strength of inhibitory transmission via a nongenomic mechanism. The functional relevance of this modulation, however, remains unknown. Here we show that estradiol generated in the songbird homolog of the mammalian auditory association cortex, rapidly enhances the effectiveness of the neural coding of complex, learned acoustic signals in awake zebra finches. Specifically, estradiol increases mutual information rates, coding efficiency, and the neural discrimination of songs. These effects are mediated by estradiol's modulation of both the rate and temporal coding of auditory signals. Interference with the local action or production of estradiol in the auditory forebrain of freely behaving animals disrupts behavioral responses to songs, but not to other behaviorally relevant communication signals. Our findings directly show that estradiol is a key regulator of auditory function in the adult vertebrate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.