ArticleJournal of neurophysiology2011
GABAergic and glycinergic inhibition modulate monaural auditory response properties in the avian superior olivary nucleus.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.The Journal of comparative neurology · 2026Article
- Single Neuron Contributions to the Auditory Brainstem EEG.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Anatomy of superior olivary complex and lateral lemniscus in Etruscan shrew.Scientific reports · 2024Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Article
- Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- TheMedical research archives · 2020Article
- Inhibitory Neural Circuits in the Mammalian Auditory Midbrain.Journal of experimental neuroscience · 2018Review
- Intrinsic physiology of inhibitory neurons changes over auditory development.Journal of neurophysiology · 2018Article
- Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse.Frontiers in cellular neuroscience · 2017Article
- The origin and evolution of vertebrate glycine transporters.Journal of molecular evolution · 2014Article
- Slowly emerging glycinergic transmission enhances inhibition in the sound localization pathway of the avian auditory system.Journal of neurophysiology · 2014Article
- Glycinergic transmission modulates GABAergic inhibition in the avian auditory pathway.Frontiers in neural circuits · 2014Article
- Coding space-time stimulus dynamics in auditory brain maps.Frontiers in physiology · 2014Review
- Circuit models and experimental noise measurements of micropipette amplifiers for extracellular neural recordings from live animals.BioMed research international · 2014Article
- Activity-dependent modulation of inhibitory synaptic kinetics in the cochlear nucleus.Frontiers in neural circuits · 2014Article
- Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Manufacturing and using piggy-back multibarrel electrodes for in vivo pharmacological manipulations of neural responses.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The superior olivary nucleus (SON) is the primary source of inhibition in the avian auditory brainstem. While much is known about the role of inhibition at the SON's target nuclei, little is known about how the SON itself processes auditory information or how inhibition modulates these properties. Additionally, the synaptic physiology of inhibitory inputs within the SON has not been described. We investigated these questions using in vivo and in vitro electrophysiological techniques in combination with immunohistochemistry in the chicken, an organism for which the auditory brainstem has otherwise been well characterized. We provide a thorough characterization of monaural response properties in the SON and the influence of inhibitory input in shaping these features. We found that the SON contains a heterogeneous mixture of response patterns to acoustic stimulation and that in most neurons these responses are modulated by both GABAergic and glycinergic inhibitory inputs. Interestingly, many SON neurons tuned to low frequencies have robust phase-locking capability and the precision of this phase locking is enhanced by inhibitory inputs. On the synaptic level, we found that evoked and spontaneous inhibitory postsynaptic currents (IPSCs) within the SON are also mediated by both GABAergic and glycinergic inhibition in all neurons tested. Analysis of spontaneous IPSCs suggests that most SON cells receive a mixture of both purely GABAergic terminals, as well as terminals from which GABA and glycine are coreleased. Evidence for glycinergic signaling within the SON is a novel result that has important implications for understanding inhibitory function in the auditory brainstem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.