ArticleAmerican journal of epidemiology2011
Associations between longitudinal changes in serum estrogen, testosterone, and bioavailable testosterone and changes in benign urologic outcomes.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Serum Testosterone and Dihydrotestosterone and Incidence and Progression of Lower Urinary Tract Symptoms: Results From the REDUCE Study.The Journal of urology · 2024Article
- Article
- Testosterone replacement therapy and voiding dysfunction.Translational andrology and urology · 2016Review
- Testosterone Replacement Therapy and BPH/LUTS. What is the Evidence?Current urology reports · 2016Review
- Testosterone Replacement Therapy on the Natural History of Prostate Disease.Current urology reports · 2015Review
- Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Benign prostatic hyperplasia: a new metabolic disease?Journal of endocrinological investigation · 2014Review
- Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.International journal of endocrinology · 2014Review
- The link between benign prostatic hyperplasia and prostate cancer.Nature reviews. Urology · 2013Review
- Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).International journal of epidemiology · 2012Article
- Office evaluation of male patients with lower urinary tract symptoms.Current urology reports · 2012Article
- Article
- Lower urinary tract symptoms and diet quality: findings from the 2000-2001 National Health and Nutrition Examination Survey.Urology · 2012Article
- [Benign prostatic hyperplasia and urolithiasis].Der Urologe. Ausg. A · 2011Review
- A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Some men have rapid increases in benign prostatic enlargement and lower urinary tract symptoms (LUTS), and it is not clear how sex steroid hormones contribute to the rates of change in these urologic outcomes. Therefore, the authors conducted a population-based cohort study of 648 men residing in Olmsted County, Minnesota, from 1990 to 2007, to examine associations between baseline sex steroid hormones, the rate of change in these hormones, and the rates of change in LUTS, maximum urinary flow rate, and prostate volume. Annual changes in hormone levels and urologic outcomes were calculated using mixed-effects regression models. Associations between hormone variables and rates of change in urologic outcomes were assessed with linear regression models. Higher baseline estradiol levels and rapid declines in estradiol over time were associated with rapid increases in LUTS and rapid decreases in maximum flow rate. Lower baseline bioavailable testosterone levels and more rapid declines in bioavailable testosterone were associated with more rapid increases in prostate volume. These results suggest that both absolute sex steroid hormone levels and the rates at which the levels change may be important in the development of urologic conditions in aging men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.