ArticleEnvironmental health perspectives2011
Assessing the ecotoxicologic hazards of a pandemic influenza medical response.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
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- Molecular characterization of Vibrio species isolated from dairy and water samples.Scientific reports · 2023Article
- Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania.Journal of environmental quality · 2022Article
- Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.The Science of the total environment · 2021Article
- A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance.Journal of hazardous materials · 2021Review
- Setting the standard: multidisciplinary hallmarks for structural, equitable and tracked antibiotic policy.BMJ global health · 2020Review
- Characterisation ofInternational journal of microbiology · 2020Article
- Translating antibiotic prescribing into antibiotic resistance in the environment: A hazard characterisation case study.PloS one · 2019Article
- Vibrio Pathogens: A Public Health Concern in Rural Water Resources in Sub-Saharan Africa.International journal of environmental research and public health · 2017Review
- Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators.Frontiers in microbiology · 2016Review
- Detection of peramivir and laninamivir, new anti-influenza drugs, in sewage effluent and river waters in Japan.PloS one · 2015Article
- Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers.PloS one · 2014Article
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9 authors.
Funding
Abstract
backgroundThe global public health community has closely monitored the unfolding of the 2009 H1N1 influenza pandemic to best mitigate its impact on society. However, little attention has been given to the impact of this response on the environment. Antivirals and antibiotics prescribed to treat influenza are excreted into wastewater in a biologically active form, which presents a new and potentially significant ecotoxicologic challenge to microorganisms responsible for wastewater nutrient removal in wastewater treatment plants (WWTPs) and receiving rivers.
objectivesWe assessed the ecotoxicologic risks of a pandemic influenza medical response.
methodsTo evaluate this risk, we coupled a global spatially structured epidemic model that simulates the quantities of antivirals and antibiotics used during an influenza pandemic of varying severity and a water quality model applied to the Thames catchment to determine predicted environmental concentrations. An additional model was then used to assess the effects of antibiotics on microorganisms in WWTPs and rivers.
resultsConsistent with expectations, our model projected a mild pandemic to exhibit a negligible ecotoxicologic hazard. In a moderate and severe pandemic, we projected WWTP toxicity to vary between 0-14% and 5-32% potentially affected fraction (PAF), respectively, and river toxicity to vary between 0-14% and 0-30% PAF, respectively, where PAF is the fraction of microbial species predicted to be growth inhibited (lower and upper 95% reference range).
conclusionsThe current medical response to pandemic influenza might result in the discharge of insufficiently treated wastewater into receiving rivers, thereby increasing the risk of eutrophication and contamination of drinking water abstraction points. Widespread drugs in the environment could hasten the generation of drug resistance. Our results highlight the need for empirical data on the effects of antibiotics and antiviral medications on WWTPs and freshwater ecotoxicity.
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