Evidence map›Paper›PMID 21367394›Full record

ArticleArchives of physical medicine and rehabilitation2011

Identifying factors associated with falls in postmenopausal breast cancer survivors: a multi-disciplinary approach.

Kerri M Winters-Stone, Britta Torgrimson, Fay Horak, Alvin Eisner, Lillian Nail, Michael C Leo, Steve Chui, Shiuh-Wen Luoh

Registry-linked trialAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02391818 (The Effect of Taxane Chemotherapy on Balance in Breast Cancer Patients), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02391818 completednot on this mapstarted 2015, after this paper: background citation

The Effect of Taxane Chemotherapy on Balance in Breast Cancer Patients

TypeobservationalSponsorOSF Healthcare SystemRan2015 to 2017Enrolled19ConditionsDistorted, Balance, Quality of Life, Neuropathy
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Pooled it
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  5. Evaluating recruitment, retention, and adherence patterns in the GET FIT fall prevention exercise trial in older, postmenopausal cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  9. Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
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  20. Bone loss induced by cancer treatments in breast and prostate cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kerri M Winters-StoneSchool of Nursing, Oregon Health and Science University, Portland, 97239, USA. wintersk@ohsu.edu
Britta Torgrimson
Fay Horak
Alvin Eisner
Lillian Nail
Michael C Leo
Steve Chui
Shiuh-Wen Luoh

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
YOUTH, Osteoporosis, and Understanding Total Health (YOUTH)M01RR000334 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DORSA, DANIEL MICHAEL · 1985 to 2006
$30.6M
Peripheral and central Postural Disorders in the ElderlyR37AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 2004 to 2013
$4.5M
Comparison of Aerobic and Resistance Exercise in Older Breast Cancer SurvivorsR01CA120123 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WINTERS-STONE, KERRI M · 2007 to 2009
$849k
NCI NIH HHS R01 CA120123NCRR NIH HHS M01 RR000334NCRR NIH HHS UL1 RR024140NIA NIH HHS R37 AG006457
6 · The paper itself

Abstract

objectiveTo identify neuromuscular, balance, and vision factors that contribute to falls in recently treated breast cancer survivors (BCS) and explore links between fall risk factors and cancer treatment.

designCase-control plus prospective observation.

settingComprehensive cancer center.

participantsBCS (N=59; mean age, 58y) within 2 years of chemotherapy completion and/or on adjuvant endocrine therapy.

interventionsNot applicable.

main outcome measuresObjective measures of postural control, vision, and neuromuscular function included: (1) a sensory organization test (SOT), (2) a visual assessment battery, (3) muscle mass by dual energy x-ray absorptiometry, and (4) neuromuscular function with strength by repetition maximum, power by timed stair climb, and gait speed by 4m walk. Falls were self-reported for the past year (retrospective) and monthly for 6 months (prospective).

resultsFifty eight percent of BCS reported falls in the past year. BCS with a history of falls had lower SOT scores with a vestibular deficit pattern in postural control (P<.01) and took longer to read letters on the contrast sensitivity chart (P<.05). Vestibular score on the SOT mediated the relationship between treatment and falls among BCS who received chemotherapy only, but not adjuvant endocrine therapy.

conclusionsResults of this project suggest that balance disturbances of vestibular origin and delays in detecting low contrast visual stimuli are associated with falls in BCS. Future studies that track falls and fall risk factors in BCS from diagnosis through treatment are warranted, as are studies that can identify treatment-related vestibular dysfunction and altered visual processing.

Indexed as

Absorptiometry, PhotonAccidental FallsBreast NeoplasmsCase-Control StudiesDepth PerceptionFemaleGaitHumansMiddle AgedMuscle StrengthPostural BalanceProspective StudiesRegression AnalysisRisk FactorsVisual Acuity

Identifiers

PMID21367394
PMCPMC3430739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.