ArticleBMC evolutionary biology2011
Functional conservation of the Drosophila hybrid incompatibility gene Lhr.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 28 citations in OpenAlex.
- Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Review
- Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly.Nucleic acids research · 2025Article
- The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.PLoS genetics · 2021Article
- White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter.Nature communications · 2021Article
- Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution.Progress in molecular and subcellular biology · 2021Article
- Protein Complexes Form a Basis for Complex Hybrid Incompatibility.Frontiers in genetics · 2021Review
- Insights into HP1a-Chromatin Interactions.Cells · 2020Review
- Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.Scientific reports · 2020Article
- Article
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins.PloS one · 2015Article
- Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs.Genes & development · 2014Article
- The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.PLoS genetics · 2014Article
- X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.PLoS genetics · 2014Article
- Article
- An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is functionally relevant.Genetics · 2012Article
- Cis-by-Trans regulatory divergence causes the asymmetric lethal effects of an ancestral hybrid incompatibility gene.PLoS genetics · 2012Article
- Chromatin evolution and molecular drive in speciation.International journal of evolutionary biology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHybrid incompatibilities such as sterility and lethality are commonly modeled as being caused by interactions between two genes, each of which has diverged separately in one of the hybridizing lineages. The gene Lethal hybrid rescue (Lhr) encodes a rapidly evolving heterochromatin protein that causes lethality of hybrid males in crosses between Drosophila melanogaster females and D. simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene.
resultsHere we have examined the functional properties of Lhr orthologs from multiple Drosophila species, including interactions with other heterochromatin proteins, localization to heterochromatin, and ability to complement hybrid rescue in D. melanogaster/D. simulans hybrids. We find that these properties are conserved among most Lhr orthologs, including Lhr from D. melanogaster, D. simulans and the outgroup species D. yakuba.
conclusionsWe conclude that evolution of the hybrid lethality properties of Lhr between D. melanogaster and D. simulans did not involve extensive loss or gain of functions associated with protein interactions or localization to heterochromatin.
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