ArticleBMC surgery2011
Myofibroblasts and colonic anastomosis healing in Wistar rats.
Article in BMC surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Ameliorative role of silver nanoparticles incorporated with chitosan solution and leukocyte platelet-rich fibrin scaffold during colon anastomosis in rabbits.Journal of materials science. Materials in medicine · 2025Article
- Innovative approach: utilizing silver nanoparticles sheet for improved rabbit cecal anastomosis healing.Frontiers in veterinary science · 2024Article
- Evaluation of the Effect of an Intraperitoneal Cytostatic-Loaded Supramolecular Hydrogel on Intestinal Anastomotic Healing in an Animal Model.Life (Basel, Switzerland) · 2023Article
- Intraperitoneal BromAcCancers · 2023Article
- Establishment of a mouse model for bile duct repair and tissue engineering.Experimental and therapeutic medicine · 2022Article
- Improved Healing of Colonic Anastomosis with Allotransplantation of Axillary Skin Fibroblasts in Rats.Cell journal · 2022Article
- Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model.Scientific reports · 2020Article
- Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing.Gastroenterology research and practice · 2020Article
- Effect of thymoquinone on the healing of left colon anastomosis: an experimental study.SpringerPlus · 2016Article
- GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.Surgical infections · 2015Article
- Bovine pericardium patch wrapping intestinal anastomosis improves healing process and prevents leakage in a pig model.PloS one · 2014Article
- Examining the safety of colon anastomosis on a rat model of ischemia-reperfusion injury.World journal of emergency surgery : WJES · 2013Article
- Tamoxifen decreases the myofibroblast count in the healing bile duct tissue of pigs.Clinics (Sao Paulo, Brazil) · 2013Article
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats.Cell transplantationArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe myofibroblasts play a central role in wound healing throughout the body. The process of wound healing in the colon was evaluated with emphasis on the role of myofibroblasts.
methodsOne hundred male Wistar rats weighing 274 ± 9.1 g (mean age: 3.5 months) were used. A left colonic segment was transected and the colon was re-anastomosed. Animals were randomly divided into two groups. The first group experimental animals (n = 50) were sacrificed on postoperative day 3, while the second group rats (n = 50) were sacrificed on postoperative day 7. Healing of colonic anastomosis was studied in terms of anastomotic bursting pressure, as well as myofibroblastic reaction and expression of α-smooth muscle actin (α-SMA), adhesion formation, inflammatory reaction and neovascularization.
resultsThe mean anastomotic bursting pressure increased from 20.6 ± 3.5 mmHg on the 3rd postoperative day to 148.8 ± 9.6 Hg on the 7th postoperative day. Adhesion formation was increased on the 7th day, as compared to the 3rd day. In addition, the myofibroblastic reaction was more profound on the 7th postoperative day in comparison with the 3rd postoperative day. The staining intensity for α-SMA was progressive from the 3rd to the 7th postoperative day. On the 7th day the α-SMA staining in the myofibroblats reached the level of muscular layer cells.
conclusionsOur study emphasizes the pivotal role of myofibroblasts in the process of colonic anastomosis healing. The findings provide an explanation for the reduction in the incidence of wound dehiscence after the 7th postoperative day.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.