ReviewParasite immunology2011
Parasite-driven pathogenesis in Trypanosoma brucei infections.
Review in Parasite immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Immunoinformatics Approach for the Designing of a Novel mRNA Vaccine Candidate Against Trypanosoma brucei.Acta parasitologica · 2026Article
- The pathogenicity of blood stream and central nervous system forms ofF1000Research · 2022Article
- Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans.Frontiers in cellular and infection microbiology · 2021Review
- New Molecular Approach for the Detection of Kinetoplastida Parasites of Medical and Veterinary Interest.Microorganisms · 2020Article
- Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins ofVaccines · 2020Article
- The role of vascular endothelium and exosomes in human protozoan parasitic diseases.Vessel plus · 2020Article
- SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-ACS medicinal chemistry letters · 2019Article
- Novel lead compounds in pre-clinical development against African sleeping sickness.MedChemComm · 2017Review
- Differential virulence and tsetse fly transmissibility ofThe Onderstepoort journal of veterinary research · 2017Article
- The evolution of trypanosomatid taxonomy.Parasites & vectors · 2017Review
- An Overview ofFrontiers in microbiology · 2016Review
- Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei.Antimicrobial agents and chemotherapy · 2015Article
- The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death inMicrobial cell (Graz, Austria) · 2015Article
- The molecular arms race between African trypanosomes and humans.Nature reviews. Microbiology · 2014Review
- Redox-assisted protein folding systems in eukaryotic parasites.Antioxidants & redox signaling · 2012Review
- Untreated human infections by Trypanosoma brucei gambiense are not 100% fatal.PLoS neglected tropical diseases · 2012Article
- African trypanosomiasis.Parasite immunology · 2011Article
Corrections and comments
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1 author.
Funding
Abstract
Trypanosomes are protozoan parasites of medical and veterinary importance. It is well established that different species, subspecies and strains of trypanosome can cause very different disease in the mammalian host, exemplified by the two human-infective subspecies of Trypanosoma brucei that cause either acute or chronic disease. We are beginning to understand how the host response shapes the course of the disease and how genetic variation in the host can be a factor in disease severity, particularly in the mouse model, but until recently the role of parasite genetic variation that determines differential disease outcome has been a neglected area. This review will discuss the recent advances in this field, covering both our current knowledge of the T. brucei genes involved and the approaches that are leading towards the identification of T. brucei virulence genes. Finally, the potential for using parasite genotype variation to examine the evolutionary context of virulence will be discussed.
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Registered trials
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