ReviewFuture microbiology2011
Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview.
Review in Future microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Leprosy in skeletons from archaeological sites: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- The Neurological Impact of Leprosy: Manifestations and Treatment Approaches.Neurology international · 2024Review
- Article
- The landscape of chemokine and cytokine is associated with the distinct clinical status of leprosy patients and their respective household contacts.Frontiers in immunology · 2024Article
- Xenophagy as a Strategy forPathogens (Basel, Switzerland) · 2023Review
- Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case-Control Study in a Colombian Population.Tropical medicine and infectious disease · 2023Article
- Evidencing leprosy neuronal inflammation by 18-Fluoro-deoxy-glucose.PLoS neglected tropical diseases · 2023Article
- Article
- Cytokines profile in pure neural leprosy.Frontiers in immunology · 2023Article
- Protective Efficacy of BCG Vaccine againstVaccines · 2022Review
- Leptin Deficiency May Influence the Divergence of Cell-Mediated Immunity Between Lepromatous and Tuberculoid Leprosy Patients.Journal of inflammation research · 2022Review
- Biosynthetic Glycan Labeling.Journal of the American Chemical Society · 2021Article
- Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts.Infectious diseases of poverty · 2020Article
- Expression of annexin-A1 in blood and tissue leukocytes of leprosy patients.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Biomarkers for Detecting Resilience against Mycobacterial Disease in Animals.Infection and immunity · 2019Review
- Trends of leprosy and multibacillary infection in the state of Georgia since the early 1900s.PLoS neglected tropical diseases · 2019Article
- Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas.Emerging infectious diseases · 2019Article
- CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy.Frontiers in immunology · 2019Article
- Comparative genome sequencing and analyses of Mycobacterium cosmeticum reveal potential for biodesulfization of gasoline.PloS one · 2019Article
- The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species.Microbiome · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae in which susceptibility to the mycobacteria and its clinical manifestations are attributed to the host immune response. Even though leprosy prevalence has decreased dramatically, the high number of new cases indicates active transmission. Owing to its singular features, M. leprae infection is an attractive model for investigating the regulation of human immune responses to pathogen-induced disease. Leprosy is one of the most common causes of nontraumatic peripheral neuropathy worldwide. The proportion of patients with disabilities is affected by the type of leprosy and delay in diagnosis. This article briefly reviews the clinical features as well as the immunopathological mechanisms related to the establishment of the different polar forms of leprosy, the mechanisms related to M. leprae-host cell interactions and prophylaxis and diagnosis of this complex disease. Host genetic factors are summarized and the impact of the development of interventions that prevent, reverse or limit leprosy-related nerve impairments are discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.