ArticleJournal of neurology2011
Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid.
Article in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Clinical and imaging features of lymphomatosis cerebri: analysis of 8 cases and systematic review of the literature.Clinical and experimental medicine · 2023Pooled it
- Lymphomatosis cerebri: a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature.Neuro-oncology · 2016Pooled it
- A Case of Lymphomatosis Cerebri Presenting with Rapid Progression of Dementia: A Literature Review.NMC case report journal · 2022Article
- Primary diffuse large B-cell lymphoma of the CNS, with a "Lymphomatosis cerebri" pattern.Autopsy & case reports · 2021Article
- Case Report: Paraneoplastic Hashimoto's Encephalopathy Associated With Lymphomatosis Cerebri With Periodic Synchronous Discharges Resembling Creutzfeldt-Jakob Disease.Frontiers in neurology · 2021Article
- Neuroradiological features of lymphomatosis cerebri: A systematic review of the English literature with a new case report.Oncology letters · 2018Article
- Lymphomatosis cerebri: diagnostic challenges and review of the literature.BMJ case reports · 2016Review
- Neurocognitive features distinguishing primary central nervous system lymphoma from other possible causes of rapidly progressive dementia.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2015Article
- Lymphomatosis cerebri: a treatable cause of rapidly progressive dementia.Journal of neurology, neurosurgery, and psychiatry · 2015Article
- Lymphomatosis cerebri presenting with orthostatic hypotension, anorexia, and paraparesis.Journal of neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a case of a patient with a rapidly progressive dementing illness and gait disturbance, in whom initial screening demonstrated a high methylmalonic acid level only, suggestive of a functional vitamin B(12) deficiency. Despite B(12) replacement therapy, he continued to decline. Further investigations demonstrated extensive signal change on magnetic resonance imaging involving grey and white matter within the corpus callosum, deep grey matter, brainstem and cerebellar peduncles, and patchy post-contrast enhancement. Laboratory testing revealed a raised erythrocyte sedimentation rate, raised anti-nuclear, intrinsic factor and lupus anticoagulant antibody titres, and a IgG kappa paraprotein. Cerebrospinal fluid was unremarkable. Bone marrow trephine biopsy showed monoclonal gammopathy of unknown significance. The patient initially responded to steroids, and underwent a brain biopsy, which was uninformative. However, 3 weeks following admission, he died due to an aspiration pneumonia. Autopsy findings were consistent with a diffuse primary central nervous system small cell B-cell lymphoma. This has been rarely reported in the medical literature, but our case exhibits typical clinical features, although patchy enhancement on imaging and the high methylmalonic acid have not been previously described. We hypothesise that his functional B(12) deficiency may have resulted from rapid cell turnover, perhaps in conjunction with the presence of intrinsic factor antibodies.
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