ArticleInternational urogynecology journal2011
Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies.
Article in International urogynecology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A systematic review and meta-analysis on the efficacy of intravesical therapy for bladder pain syndrome/interstitial cystitis.International urogynecology journal · 2016Pooled it
- Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges.BJU international · 2013Pooled it
- Review
- The efficacy and safety of intravesical chondroitin sulphate solution in recurrent urinary tract infections.BMC urology · 2022Article
- Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis.International urogynecology journal · 2021Article
- Radiation-induced haemorrhagic cystitis after prostate cancer radiotherapy: factors associated to hospitalization and treatment strategies.Prostate international · 2021Article
- Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats.Acta cirurgica brasileira · 2021Article
- Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives.Cells · 2020Review
- Gold nanoparticles approach to detect chondroitin sulphate and hyaluronic acid urothelial coating.Scientific reports · 2017Article
- [Radiation cystitis : Pathophysiology and treatment].Der Urologe. Ausg. A · 2017Review
- Intravesical Therapies for Radiation Cystitis.Current urology · 2015Review
- Review
- Intravesical Glycosaminoglycan Replacement with Chondroitin Sulphate (Gepan(®) instill) in Patients with Chronic Radiotherapy- or Chemotherapy-Associated Cystitis.Clinical drug investigation · 2015Observational
- A Narrative Review on the Pathophysiology and Management for Radiation Cystitis.Advances in urology · 2015Review
- Treatment of acute radiation cystitis: comment.International urogynecology journal · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisWe studied the feasibility and efficacy of intravesical instillations with 40 ml chondroitin sulfate 0.2% solution to prevent or reduce acute radiation cystitis in women undergoing pelvic radiotherapy.
methodsIn a comparative pilot study in 20 patients, half of the patients received instillations. Instillations' bother was measured with visual analog scores (VAS, 0-10); bladder pain, with VAS; micturition-related quality of life, with the urogenital distress inventory (UDI).
resultsOne of the instilled patients discontinued the instillations. The first median "acceptability"-VAS was 0 (range, 0-3); the last median was 1 (range, 0-3). "Bladder pain"-VAS peaked halfway in the treatment among controls (median, 1; range, 0-5) and after treatment in the instilled patients (median, 1; range, 1-3). UDI scores showed over time median follow-up scores at or above median baseline scores in controls and at or below median baseline scores in instilled patients.
conclusionIntravesical instillations with chondroitin sulfate 0.2% solution may decrease the bother related to bladder symptoms and are well tolerated.
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