ArticleMolecular imaging and biology2012
The effect of inhaled gases on ultrasound contrast agent longevity in vivo.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Hepatic Histotripsy after Contrast-Enhanced Ultrasound: Evaluation of Safety and Efficacy in an In Vivo Swine Model.Journal of vascular and interventional radiology : JVIR · 2026Article
- High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Phospholipid Oxygen Microbubbles for Image-Guided Therapy.Nanotheranostics · 2020Article
- In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study.Journal of neuroinflammation · 2019Article
- Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability.Expert opinion on drug delivery · 2019Review
- MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease.Scientific reports · 2018Article
- MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.Theranostics · 2018Article
- Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions.Theranostics · 2018Article
- Reply to Silburt et al.: Concerning sterile inflammation following focused ultrasound and microbubbles in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Effects of Oxygen on Ultrasound-Induced Blood-Brain Barrier Disruption in Mice.Ultrasound in medicine & biology · 2017Article
- Blood-Brain Barrier Opening in Behaving Non-Human Primates via Focused Ultrasound with Systemically Administered Microbubbles.Scientific reports · 2015Article
- Biomarkers in preclinical cancer imaging.European journal of nuclear medicine and molecular imaging · 2015Review
- Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom.Ultrasound in medicine & biology · 2012Article
- Blood-brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocol.Ultrasound in medicine & biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study is to investigate the effect of the inhaled gas used alongside isoflurane in the anesthetization of small animals on the time-intensity curves (TICs) acquired from ultrasound contrast agents--microbubbles. PROCEDURES: TICs were recorded over the common iliac vein of 12 mice receiving Definity®. Animals were anesthetized with isoflurane, the ventilator was driven by medical air (MA), then in random order, the driving gas was changed for 3 min to: MA (control); pure oxygen (O₂; O₂ + perfluorohexane (PFH:O₂; or O₂ + octafluoropropane (OFP:O₂), the perfluorocarbon (PFC) in Definity, followed by a return to MA 3 min later.
resultsThe mean slope of signal decay was -0.47, -1.05, -1.16, and -1.42 video-intensity units/s for MA, OFP:O₂, PFH:O₂, and O₂, respectively; MA had the slowest decay (p < 0.0001). Both PFC mixtures had slower signal decay than O₂, but only OFP:O₂ was significant (p < 0.01). When MA was used immediately following dosing, slope gradually decreased (p = 0.032) and was two times slower by the fourth injection (p = 0.012).
conclusionsMicrobubble kinetics are closely associated with the driving gas for inhaled anesthesia. MA has the least effect and should be used when inhaled anesthesia is used. Furthermore, when animals are given multiple injections in the same session, microbubbles last longer with subsequent injections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.