ArticleCellular and molecular life sciences : CMLS2011
Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- RNAi-Mediated Silencing of Pgants Shows Core 1Frontiers in physiology · 2021Article
- Article
- Synthesis and biological roles of O-glycans in insects.Glycoconjugate journal · 2020Review
- Functional analysis of glycosylation using Drosophila melanogaster.Glycoconjugate journal · 2020Review
- Regulation of Carbohydrate Energy Metabolism inGenetics · 2017Review
- O-GlcNAcylation: a bridge between glucose and cell differentiation.Journal of cellular and molecular medicine · 2016Review
- O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster.Cellular and molecular life sciences : CMLS · 2015Article
- O-GlcNAc reports ambient temperature and confers heat resistance on ectotherm development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The N's and O's of Drosophila glycoprotein glycobiology.Glycoconjugate journal · 2013Review
- The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo.The Journal of biological chemistry · 2012Article
- A role for O-GlcNAcylation in setting circadian clock speed.Genes & development · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This increase in growth is due mainly to cell growth and not to cell proliferation. Our data suggest that the increase in the insulin signaling activity is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling during Drosophila development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.