ArticleClinical rheumatology2011
Diagnostic value of pathergy test in Behcet's disease according to the change of incidence over the time.
Article in Clinical rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology and clinical features of Behçet's disease in the Middle East and North Africa:A systematic review and meta-analysis.Clinical rheumatology · 2026Pooled it
- A Systematic Review of Neurocognitive Functioning in Behçet's Disease.Neuropsychology review · 2019Pooled it
- Complex vasculitic overlap: temporal arteritis complicating suspected neuro-behçet disease with recurrent ischemic injury.BMC neurology · 2026Article
- Phenotype-associated microvascular differences in pediatric Behçet's disease revealed by nailfold videocapillaroscopy.European journal of pediatrics · 2026Article
- Myelodysplastic Syndrome With Complex Chromosomal Karyotype Abnormalities Complicated by Multiple Intestinal Perforations: A Case Report and Literature Review.Case reports in gastrointestinal medicine · 2026Article
- Behçet's disease unraveled: Insights into clinical manifestations, diagnosis, and management.Medicine · 2025Review
- High prevalence of HLA-B51 and ocular involvement in Behçet's disease: a multicenter cross-sectional study.Rheumatology international · 2025Article
- Multisystemic Manifestations of Behcet's Disease and Its Treatment Outcome: A Case Report and Review of the Literature.Clinical case reports · 2025Article
- [Pathogenesis and treatment progression of myelodysplastic syndrome combined with BehçetZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Clinical profiling, treatment characteristics and outcome in Behcet's Disease (BD)-A retrospective cohort study from Karnataka Rheumatology Association (KRA).Clinical rheumatology · 2024Article
- Behcet disease: A case report on the utilization of T1-weighted black blood fat-suppressed sequences for the detection of venous vasculitis.Clinical case reports · 2024Article
- Clinical manifestations of Behçet's syndrome: A single-center cohort of 777 patients.European journal of rheumatology · 2021Article
- Correlation of clinical signs and symptoms of Behçet's disease with platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR).Immunologic research · 2021Article
- Pathergy test with a 23G needle with and without self-saliva in patients with Behçet's disease, recurrent aphthous stomatitis and control group compared to the 20G test.Reumatologia · 2021Article
- Pathergy Phenomenon.Frontiers in medicine · 2021Review
- Clinical features of Behcet's disease in Mongolia: a multicenter study.Clinical rheumatology · 2020Article
- Behçet's disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature.Clinical rheumatology · 2019Article
- Pathergy testing: prospective comparison of dermatoscopic evaluation and naked eye examination.Internal and emergency medicine · 2019Article
- Diagnostic/classification criteria in pediatric Behçet's disease.Rheumatology international · 2019Review
- Laryngoceles with airway compromise complicating mucous membrane pemphigoid.BMJ case reports · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathergy test (PT) is used for the diagnosis of Behcet's disease (BD). It is a criterion in many classification/diagnosis criteria. PT is mainly seen in BD but can be seen in other conditions too. PT has been reported with high frequency from most countries along the Silk Road. The sensitivity of pathergy phenomenon (PP) is declining over the time. The aim of this study was to look for the diagnostic value of PT in the past and at the present time. The BD registry (Rheumatology Research Center, Tehran University of Medical Sciences) has the data of 6,607 BD and 4,292 control patients. Patients and controls were divided in four groups of 1,650 BD and 1,073 controls. Sensitivity, specificity, positive and negative predictive value (PPV-NPV), positive and negative likelihood ratio (PLR-NLR), diagnostic odds ratio (DOR), and Youden's index (YI) were calculated for each group. The first and the fourth quartiles were compared. Sensitivity of PT decreased from 64.2% (first quartile) to 35.8% (fourth quartile). Specificity improved from 86.6% to 98.4%. PPV improved from 82.7% to 95.7%. NPV decreased from 82.7% to 60.5%. PLR improved from 4.8 to 22.4, while NLR deteriorated from 0.41 to 0.65. DOR improved from 11.6 to 34.3. Yuden's index worsened from 0.5 to 0.34. Although sensitivity of PP decreased, the increase of specificity is a plus value for diagnosis. As a result, PPV, PLR, and DOR improved, while NPR, NLR, and YI deteriorated. Although the pathergy test lost its sensitivity during the past 35 years, it has not lost its value as a diagnostic test, improving many of its characteristics. In a practical view, the chances of getting a positive test have decreased over the time. However, a positive test is rather the synonym of Behcet's disease, with a probability of 98.4%.
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