Trial reportPloS one2011
Neuromuscular consequences of an extreme mountain ultra-marathon.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02014233 (The Effect of Short Term Omega-3 Supplementation on Exercise Performance and Neuromuscular Function.), which is not on this map. Cited by 106 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Short Term Omega-3 Supplementation on Exercise Performance and Neuromuscular Function.
Who cites it
106 citing papers in PubMed, 1 synthesis or guideline pooled it, 241 citations in OpenAlex.
- Relationship of Carbohydrate Intake during a Single-Stage One-Day Ultra-Trail Race with Fatigue Outcomes and Gastrointestinal Problems: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Caffeine ingestion increases endurance performance of trained male cyclists when riding against a virtual opponent without altering muscle fatigue.European journal of applied physiology · 2022Trial
- The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training.Journal of the International Society of Sports Nutrition · 2020Trial
- Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners.Nutrients · 2020Trial
- The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners.Journal of the International Society of Sports Nutrition · 2020Trial
- Neuromuscular adaptations to sprint interval training and the effect of mammalian omega-3 fatty acid supplementation.European journal of applied physiology · 2017Trial
- Effect of the Fatigue Induced by a 110-km Ultramarathon on Tibial Impact Acceleration and Lower Leg Kinematics.PloS one · 2016Trial
- Combining heat stress and moderate hypoxia reduces cycling time to exhaustion without modifying neuromuscular fatigue characteristics.European journal of applied physiology · 2014Trial
- High-intensity sprint fatigue does not alter constant-submaximal velocity running mechanics and spring-mass behavior.European journal of applied physiology · 2012Trial
- Effects of extreme-duration heavy load carriage on neuromuscular function and locomotion: a military-based study.PloS one · 2012Trial
- Hitting the Wall in Marathon Running: An Integrative Psychophysiological and Durability-Based Review.Journal of functional morphology and kinesiology · 2026Review
- Project FURTHER: A Physiological, Biomechanical, and Psychosocial Profile of an All-Female 6-Day Ultramarathon Race.Sports medicine - open · 2026Article
- Oxy-Inflammatory Profile of Finishers and No-Finishers in an Extreme Ultra-Endurance Trail Race: The 866 km Transpyrénéa.International journal of molecular sciences · 2026Article
- Review
- An all-out sprint does not challenge the main goal of an endurance-based training session in cycling.European journal of applied physiology · 2026Article
- Downhill Running-Induced Muscle Damage in Trail Runners: An Exploratory Study Regarding Training Background and Running Gait.Sports (Basel, Switzerland) · 2026Article
- The impact of pole use on vertical cost of transport and foot force during uphill treadmill walking before and after a simulated trail running competition.European journal of applied physiology · 2026Article
- Comment on: "Sports Dietitians Australia and Ultra Sports Science Foundation Joint Position Statement: A Practitioner Guide to the Prevention and Management of Exercise-Associated Gastrointestinal Perturbations and Symptoms".Sports medicine (Auckland, N.Z.) · 2025Article
- Etiology and recovery of knee extensor muscle fatigue following simulated basketball match-play.Biology of sport · 2025Article
- Decoding Ultramarathon: Muscle Damage as the Main Impediment to Performance.Sports medicine (Auckland, N.Z.) · 2025Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the physiological consequences of one of the most extreme exercises realized by humans in race conditions: a 166-km mountain ultra-marathon (MUM) with 9500 m of positive and negative elevation change. For this purpose, (i) the fatigue induced by the MUM and (ii) the recovery processes over two weeks were assessed. Evaluation of neuromuscular function (NMF) and blood markers of muscle damage and inflammation were performed before and immediately following (n = 22), and 2, 5, 9 and 16 days after the MUM (n = 11) in experienced ultra-marathon runners. Large maximal voluntary contraction decreases occurred after MUM (-35% [95% CI: -28 to -42%] and -39% [95% CI: -32 to -46%] for KE and PF, respectively), with alteration of maximal voluntary activation, mainly for KE (-19% [95% CI: -7 to -32%]). Significant modifications in markers of muscle damage and inflammation were observed after the MUM as suggested by the large changes in creatine kinase (from 144 ± 94 to 13,633 ± 12,626 UI L(-1)), myoglobin (from 32 ± 22 to 1,432 ± 1,209 µg L(-1)), and C-Reactive Protein (from <2.0 to 37.7 ± 26.5 mg L(-1)). Moderate to large reductions in maximal compound muscle action potential amplitude, high-frequency doublet force, and low frequency fatigue (index of excitation-contraction coupling alteration) were also observed for both muscle groups. Sixteen days after MUM, NMF had returned to initial values, with most of the recovery process occurring within 9 days of the race. These findings suggest that the large alterations in NMF after an ultra-marathon race are multi-factorial, including failure of excitation-contraction coupling, which has never been described after prolonged running. It is also concluded that as early as two weeks after such an extreme running exercise, maximal force capacities have returned to baseline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.