ArticlePloS one2011
TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness.International journal of molecular sciences · 2024Article
- When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment.Frontiers in molecular biosciences · 2023Review
- 17β-Estradiol Protects the Retinal Nerve Cells Suppressing TLR2 Mediated Immune-Inflammation and Apoptosis from Oxidative Stress Insult Independent of PI3K.Journal of molecular neuroscience : MN · 2016Article
- Patient perspectives on fluticasone-vilanterol versus other corticosteroid combination products for the treatment of asthma.Patient preference and adherence · 2016Review
- Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma.Mediators of inflammation · 2016Review
- Inactivated influenza virus vaccine is efficient and reduces IL-4 and IL-6 in allergic asthma mice.Influenza and other respiratory viruses · 2013Article
- Toll-like receptor 7 rapidly relaxes human airways.American journal of respiratory and critical care medicine · 2013Article
- Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata.Frontiers in microbiology · 2013Article
- The therapeutic potential of Toll-like receptor 7 stimulation in asthma.Inflammation & allergy drug targets · 2012Review
- Upping the antedrug: is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?British journal of pharmacology · 2012Article
- Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats.Molecular biology reports · 2012Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToll-like receptors (TLRs) as pattern recognition receptors, participate in both innate and adaptive immune responses, and seem to play an important role in the pathogenesis of asthma. This study aimed to identify key TLRs involved in antigen induced pulmonary inflammation (AIPI), a rat model for asthma, and to explore the role of TLRs in the disease development. METHODS AND
findingsE3 rats were sensitized with ovalbumin (OVA)/alum intraperitoneally and intranasally challenged with OVA to induce AIPI model. TLR1-9 and cytokine mRNA expression in spleen, lung and mediastinal lymph node (mLN) tissues were screened by quantitative real-time polymerase chain reaction. TLR7 expression was found to be significantly down-regulated in spleen while TLR3 and TLR8 expression was up-regulated in mLN of AIPI rats. Furthermore, imiquimod (a ligand of TLR7) and TLR3 specific short-hairpin RNA plasmid for RNA interference were administrated, respectively, in vivo to AIPI rats to observe their effects on the disease by assessing various asthmatic parameters. The numbers of total cells, eosinophils, macrophages and lymphocytes were counted according to differential morphology in bronchoalveolar lavage fluid. Serum IgE and OVA specific IgG(1) concentration was detected by enzyme-linked immunosorbent assay. The results showed that both TLR7 ligand treatment and TLR3 RNAi in vivo decreased serum IgE level and interleukin-4 mRNA expression. CONCLUSION/SIGNIFICANCE: TLR3 in mLN and TLR7 in spleen both systemically modulate disease development in AIPI rats via altering serum IgE concentration relevant to Th2 responses. And these findings may provide an important clue for further research in the asthma pathogenesis and suggest a new remedy for asthma treatment.
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