ArticleEuropean journal of human genetics : EJHG2011
Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us?
Article in European journal of human genetics : EJHG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Hemoglobin Genotype Frequencies in Lagos: Insights From Offspring of Hemoglobin AS Mothers.Cureus · 2025Article
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- Measuring the Efficiency of Purging by non-random Mating in Human Populations.Molecular biology and evolution · 2024Article
- Guidelines for genetic ancestry inference created through roundtable discussions.HGG advances · 2023Article
- Population-based change-point detection for the identification of homozygosity islands.Bioinformatics (Oxford, England) · 2023Article
- Fine-scale population structure and demographic history of British Pakistanis.Nature communications · 2021Article
- The Global, Regional, and National Burden of Psoriasis: Results and Insights From the Global Burden of Disease 2019 Study.Frontiers in medicine · 2021Article
- The structure of first-cousin marriages in Brazil.Scientific reports · 2020Article
- Relatedness coefficients in pedigrees with inbred founders.Journal of mathematical biology · 2020Article
- A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences.PloS one · 2020Article
- From matrimonial practices to genetic diversity in Southeast Asian populations: the signature of the matrilineal puzzle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Genomic evidence for MHC disassortative mating in humans.Proceedings. Biological sciences · 2019Article
- Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy.Scientific reports · 2018Article
- Runs of homozygosity: windows into population history and trait architecture.Nature reviews. Genetics · 2018Review
- Inbreeding estimates in human populations: Applying new approaches to an admixed Brazilian isolate.PloS one · 2018Article
- Composite likelihood method for inferring local pedigrees.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Inbreeding coefficients and consanguineous mating types are usually inferred from population surveys or pedigree studies. Here, we present a method to estimate them from dense genome-wide single-nucleotide polymorphism genotypes and apply it to 940 unrelated individuals from the Human Genome Diversity Panel (HGDP-CEPH). Inbreeding is observed in almost all populations of the panel, and the highest inbreeding levels and frequencies of inbred individuals are found in populations of the Middle East, Central South Asia and the Americas. In these regions, first cousin (1C) marriages are the most frequent, but we also observed marriages between double first cousins (2 × 1C) and between avuncular (AV) pairs. Interestingly, if 2 × 1C marriages are preferred to AV marriages in Central South Asia and the Middle East, the contrary is found in the Americas. There are thus some regional trends but there are also some important differences between populations within a region. Individual results can be found on the CEPH website at ftp://ftp.cephb.fr/hgdp_hbd/.
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