ReviewCell death & disease2010
Bcl-2-regulated cell death signalling in the prevention of autoimmunity.
Review in Cell death & disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 93 citations in OpenAlex.
- Pharmacokinetics of the B-Cell Lymphoma 2 (Bcl-2) Inhibitor Venetoclax in Female Subjects with Systemic Lupus Erythematosus.Clinical pharmacokinetics · 2018Trial
- Venetoclax as a trigger for autoimmune hemolytic anemia in secondary acute myeloid leukemia: A case report.SAGE open medical case reports · 2026Article
- The broad impact of cell death genes on the human disease phenome.Cell death & disease · 2024Article
- Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy.Journal of neuroinflammation · 2023Article
- Regulation of Apoptosis and Oxidative Stress by Oral Boswellia Serrata Gum Resin Extract in a Rat Model of Endometriosis.International journal of molecular sciences · 2022Article
- The adaptation model of immunity: Is the goal of central tolerance to eliminate defective T cells or self-reactive T cells?Scandinavian journal of immunology · 2022Article
- Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease.Respiratory research · 2022Article
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.Frontiers in immunology · 2022Review
- Autoimmune Responses in Oncology: Causes and Significance.International journal of molecular sciences · 2021Review
- The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model.Scientific reports · 2021Article
- Function and Characterization of an Alanine Dehydrogenase Homolog FromFrontiers in veterinary science · 2021Article
- Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk.Frontiers in immunology · 2021Article
- Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.Molecular medicine reports · 2020Article
- Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors.Frontiers in immunology · 2020Review
- Current translational potential and underlying molecular mechanisms of necroptosis.Cell death & disease · 2019Review
- Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism.Cancer immunology, immunotherapy : CII · 2019Review
- Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional AdvantageFrontiers in immunology · 2019Article
- c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors.The Journal of biological chemistry · 2018Article
- Bcl-2 on the brink of breakthroughs in cancer treatment.Cell death and differentiation · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.