ArticleThe American journal of gastroenterology2011
Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms.
Article in The American journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.Health technology assessment (Winchester, England) · 2022Pooled it
- Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis.The American journal of gastroenterology · 2017Pooled it
- Guideline
- Impact of celiac disease on the clinical course of inflammatory bowel disease: CEL_EII study by GETECCU.Therapeutic advances in gastroenterology · 2026Article
- Prevalence of vomiting and nausea and associated factors after chronic and acute gluten exposure in celiac disease.BMC gastroenterology · 2023Review
- Celiac Disease Presenting in a Community-Based Gastroenterology Practice: Obesity and Bone Disease Are Common.Digestive diseases and sciences · 2023Article
- Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet.Scientific reports · 2022Article
- Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting.Scientific reports · 2022Observational
- Compliance with Gluten Free Diet Is Associated with Better Quality of Life in Celiac Disease.Nutrients · 2022Article
- Effective Degradation of Gluten and Its Fragments by Gluten-Specific Peptidases: A Review on Application for the Treatment of Patients with Gluten Sensitivity.Pharmaceutics · 2021Review
- Knowledge and opinions of asymptomatic adolescents and their caregivers on celiac disease screening.Paediatrics & child health · 2021Article
- Is mass screening for coeliac disease a wise use of resources? A health economic evaluation.BMC gastroenterology · 2021Article
- Symptoms and biomarkers associated with undiagnosed celiac seropositivity.BMC gastroenterology · 2021Article
- Do gastroenterologists have medical inertia towards coeliac disease? A UK multicentre secondary care study.BMJ open gastroenterology · 2021Article
- Ancestral Wheat Types Release Fewer Celiac Disease Related T Cell Epitopes than Common Wheat upon Ex Vivo Human Gastrointestinal Digestion.Foods (Basel, Switzerland) · 2020Article
- Rational investigations in irritable bowel syndrome.Frontline gastroenterology · 2020Article
- A Comprehensive Review of Celiac Disease/Gluten-Sensitive Enteropathies.Clinical reviews in allergy & immunology · 2019Review
- Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease.Journal of clinical gastroenterology · 2019Article
- Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh.BMJ open gastroenterology · 2019Article
- Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?Gastroenterology research and practice · 2019Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe prevalence of diagnosed celiac disease is <1 in 2,000 in the United States, but screening studies undertaken in European and other populations have revealed a much higher prevalence. The objective of this study was to determine the prevalence of celiac disease and the utility of screening in the general adult population of a geographically isolated area.
methodsSerum tissue transglutaminase antibodies (tTG-IgA) were measured in volunteer health-care participants aged ≥ 18 years at the annual Casper, Wyoming, Blue Envelope Health Fair blood draw. Subjects with positive tTG-IgA tests had their endomysial IgA antibodies checked. Double positives were offered endoscopy with small bowel biopsy. All subjects completed a short gastrointestinal (GI) symptom questionnaire.
resultsA total of 3,850 residents of the Natrona County had serologic evaluation for celiac disease, 34 of whom tested positive for both tTG and endomysial antibody (EMA) IgA. Excluding three individuals with previous diagnosis of celiac disease, the overall prevalence of positive celiac serology in this community sample was 0.8%. All 31 subjects were offered a small bowel biopsy. Of the 18 biopsied subjects, 17 (94%) had at least partial villous atrophy. Symptoms that were reported by the fair attendees did not predict positivity.
conclusionsScreening for celiac disease was widely accepted in this preventative health-care setting. Undiagnosed celiac disease affects 1 in 126 individuals in this Wyoming community. Most were asymptomatic or had atypical presentations. Serologic testing can readily detect this disease in a general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.