ReviewNature reviews. Endocrinology2011
Thyroid nodule guidelines: agreement, disagreement and need for future research.
Review in Nature reviews. Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04009863 (A Randomized, Open-label, Parallel-group Study to Determine the Efficacy of Sequential High-intensity Focused Ultrasound), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Open-label, Parallel-group Study to Determine the Efficacy of Sequential High-intensity Focused Ultrasound (HIFU) Ablation Versus Fixed-dose Radioiodine-131 Therapy in Moderate-sized Non-toxic Multinodular Goiter
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The EANM guideline on radioiodine therapy of benign thyroid disease.European journal of nuclear medicine and molecular imaging · 2023Guideline
- Thyroid function disorders and secondary cancer following haematopoietic stem cell transplantation in pediatrics: State of the art and practical recommendations for a risk-based follow-up.Frontiers in endocrinology · 2022Pooled it
- Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology.Oncotarget · 2017Pooled it
- LEADER 2: baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: preliminary observations.Diabetes, obesity & metabolism · 2015 · on this mapTrial
- Long-term efficacy of modified-release recombinant human thyrotropin augmented radioiodine therapy for benign multinodular goiter: results from a multicenter, international, randomized, placebo-controlled, dose-selection study.Thyroid : official journal of the American Thyroid Association · 2014Trial
- Microcalcifications in breast cancer tissue studied by X-ray absorption, emission, scattering and diffraction.Journal of applied crystallography · 2025Article
- Does Radioactive Iodine Treatment Affect Thyroid Size and Tracheal Diameter?Journal of clinical medicine · 2024Article
- Neglected massive multinodular goiter during pregnancy with dyspnea and successful normal delivery: A case report.Clinical case reports · 2023Article
- Radiofrequency ablation for thyroid Bethesda III nodules: preliminary results.European thyroid journal · 2023Article
- Progress in diagnosing and treating thyroid squamous cell carcinoma under the 5th edition of WHO classification.Frontiers in endocrinology · 2023Review
- Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging.World journal of clinical cases · 2022Article
- Accuracy of shear wave elastography in characterization of thyroid nodules in children and adolescents.Insights into imaging · 2021Article
- Long-Term Efficacy of Ultrasound-Guided Percutaneous Laser Ablation for Low-Risk Papillary Thyroid Microcarcinoma: A 5-Year Follow-Up Study.BioMed research international · 2021Article
- Nonsurgical Thermal Ablation of Thyroid Nodules: Not if, but Why, When, and How?Thyroid : official journal of the American Thyroid Association · 2020Article
- Differential diagnosis of thyroid nodules through a combination of multiple ultrasonography techniques: A decision-tree model.Experimental and therapeutic medicine · 2020Article
- Single-Fiber Laser Ablation in Treating Selected Metastatic Lymph Nodes of Papillary Thyroid Carcinoma and Benign Cold Thyroid Nodules-Preliminary Results.Lasers in surgery and medicine · 2020Article
- Comparison of Number of Passes and Cytopathological Specimen Adequacy for Thyroid Fine-Needle Aspiration Biopsy in the Absence of an On-Site Pathologist.European thyroid journal · 2020Article
- Radioisotope imaging for discriminating benign from malignant cytologically indeterminate thyroid nodules.Gland surgery · 2019Review
- Long-term outcome following laser therapy of benign cystic-solid thyroid nodules.Endocrine connections · 2019Article
- Ethanol Ablation of the Thyroid Nodules: 2018 Consensus Statement by the Korean Society of Thyroid Radiology.Korean journal of radiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reviews agreement, disagreement and need for future research of the thyroid nodule guidelines published by the British Thyroid Association, National Cancer Institute, American Thyroid Association and the joint, transatlantic effort of three large societies, the American Society of Clinical Endocrinologists, Associazione Medici Endocrinologi and the European Thyroid Association, published in 2010. Consensus exists for most topics in the various guidelines. A few areas of disagreement, such as the use of scintigraphy, are mostly due to differences in disease prevalence in different countries. Most of the discordance, for example, on the use of calcitonin screening or fine-needle aspiration cytology classification, could probably be resolved by further expert discussions, as the basis is the same published evidence. Importantly, owing to a current lack of evidence in many areas, clinically very relevant areas of uncertainty need to be addressed by further research. This situation applies, for instance, to better definition of ultrasound malignancy criteria and the evaluation of emerging new diagnostic and therapeutic techniques, including molecular markers. For clinicians who advise individual patients, these areas of uncertainty can currently only be resolved by sound management on the basis of clinical judgment, experience and patient preference.
Indexed as
Identifiers
21364517What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.