ArticleEpidemiology (Cambridge, Mass.)2011
Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes.
Article in Epidemiology (Cambridge, Mass.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis.Environmental health perspectives · 2013Pooled it
- Assessing the social and physical determinants of circumpolar population health.International journal of circumpolar health · 2013Pooled it
- Organic Pollutants and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Persistent organic pollutants and β-cell toxicity: a comprehensive review.American journal of physiology. Endocrinology and metabolism · 2022Review
- Longitudinal association of biomarkers of pesticide exposure with cardiovascular disease risk factors in youth with diabetes.Environmental research · 2020Article
- Prevalence of prediabetes and type 2 diabetes in two non-random populations aged 44-77 years in the Faroe Islands.Journal of clinical & translational endocrinology · 2019Article
- Gender differences in cognitive performance and health status in the Faroese Septuagenarians cohort.European journal of public health · 2019Article
- Persistent organic pollutants and risk of type 2 diabetes: A prospective investigation among middle-aged women in Nurses' Health Study II.Environment international · 2018Article
- Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.Epigenetics · 2018Article
- Adipose Tissue as a Site of Toxin Accumulation.Comprehensive Physiology · 2017Review
- Alterations in the programming of energy metabolism in adolescents with background exposure to dioxins, dl-PCBs and PBDEs.PloS one · 2017Article
- Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7-9 Years: A Prospective Cohort Study.Environmental health perspectives · 2016Article
- Umbilical Cord Serum 25-Hydroxyvitamin D Concentrations and Relation to Birthweight, Head Circumference and Infant Length at Age 14 Days.Paediatric and perinatal epidemiology · 2016Observational
- Polychlorinated biphenyls and links to cardiovascular disease.Environmental science and pollution research international · 2016Review
- Health effects associated with measured levels of contaminants in the Arctic.International journal of circumpolar health · 2016Article
- Overview of ongoing cohort and dietary studies in the Arctic.International journal of circumpolar health · 2016Article
- Number of Persistent Organic Pollutants Detected at High Concentrations in Blood Samples of the United States Population.PloS one · 2016Article
- Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls.Environmental research · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSome persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain.
methodsClinical examinations of 713 Faroese residents aged 70-74 years (64% of eligible population) included fasting plasma concentrations of glucose and insulin, and glycosylated hemoglobin. Lifetime exposure to persistent environmental chemicals from pilot whale and other traditional food was estimated from a dietary questionnaire and by analysis of blood samples for polychlorinated biphenyls (PCBs) and related food contaminants.
resultsSeptuagenarians with type 2 diabetes or impaired fasting glycemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. In nondiabetic subjects, the fasting insulin concentration decreased by 7% (95% CI = -12% to -2%) for each doubling of the PCB concentration after adjustment for sex and body mass index at age 20. Conversely, the fasting glucose concentration increased by 6% (-1% to 13%) for each doubling in PCB. Similar associations were seen in subjects without impaired fasting glycemia, while further adjustment for current body mass index and lipid metabolism parameters attenuated some of the associations.
conclusionsImpaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants.
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