Evidence map›Paper›PMID 21364325›Full record

ReviewEpigenetics2011

Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control.

Elizabeth Suzanne Dorn, Jeanette Gowen Cook

Open access · bronzeAbstract readReview
In one paragraph

Review in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Origins of DNA replication.PLoS genetics · 2019
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Genome maintenance in the context of 4D chromatin condensation.Cellular and molecular life sciences : CMLS · 2016
    Review
  15. Article
  16. Article
  17. Genome Duplication: The Heartbeat of Developing Organisms.Current topics in developmental biology · 2016
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elizabeth Suzanne DornDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
Jeanette Gowen Cook
Communities In Schools of Orange County · USUniversity of North Carolina at Chapel Hill · US

Funding

Replication Licensing and the Cell CycleR01GM083024 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN · 2009 to 2020
$2.9M
NIGMS NIH HHS R01 GM083024NIGMS NIH HHS R01GM083024
6 · The paper itself

Abstract

The importance of local chromatin structure in regulating replication initiation has become increasingly apparent. Most recently, histone methylation and nucleosome positioning have been added to the list of modifications demonstrated to regulate origins. In particular, the methylation states of H3K4, H3K36 and H4K20 have been associated with establishing active, repressed or poised origins depending on the timing and extent of methylation. The stability and precise positioning of nucleosomes has also been demonstrated to affect replication efficiency. Although it is not yet clear how these modifications alter the behavior of specific replication factors, ample evidence establishes their role in maintaining coordinated replication. This review will summarize recent advances in understanding these aspects of chromatin structure in DNA replication origin control.

Indexed as

EpigenomicsAnimalsCell CycleCell ProliferationChromatinDNA MethylationDNA ReplicationHistonesHumansNucleosomesProtein Processing, Post-TranslationalReplication OriginChromatinHistonesNucleosomes

Identifiers

PMID21364325
PMCPMC3230546
OpenAlexW2013925642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.