ArticlePsychosomatic medicine2011
A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.
Article in Psychosomatic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effects of Social Exclusion on Cardiovascular and Affective Reactivity to a Socially Evaluative Stressor.International journal of behavioral medicine · 2018Trial
- Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes.Biology · 2025Review
- Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure.Stress (Amsterdam, Netherlands) · 2019Review
- Influence of Serotonin Transporter SLC6A4 Genotype on the Effect of Psychosocial Stress on Cognitive Performance: An Exploratory Pilot Study.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2018Article
- The Trier Social Stress Test: Principles and practice.Neurobiology of stress · 2017Review
- Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture.Biology letters · 2016Article
- Allelic Variation of Risk for Anxiety Symptoms Moderates the Relation Between Adolescent Safety Behaviors and Social Anxiety Symptoms.Journal of psychopathology and behavioral assessment · 2015Article
- Serotonin transporter gene polymorphism modulates inflammatory cytokine responses during acute stress.Scientific reports · 2015Article
- Child maltreatment and blood pressure in young adulthood.Child abuse & neglect · 2014Article
- The role of negativity bias in political judgment: a cultural neuroscience perspective.The Behavioral and brain sciences · 2014Article
- How genes and the social environment moderate each other.American journal of public health · 2013Article
- Toward an integration of cognitive and genetic models of risk for depression.Cognition & emotion · 2013Review
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
- Cultural Neuroscience: Progress and Promise.Psychological inquiry · 2013Article
- Sex differences in physiological reactivity to acute psychosocial stress in adolescence.Psychoneuroendocrinology · 2012Review
- Epidemiology and Management of Depression Following Coronary Heart Disease Diagnosis in Women.Current cardiovascular risk reports · 2012Article
- Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.The International journal of eating disorders · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveTo examine whether a polymorphism (5-HTTLPR: serotonin transporter linked polymorphic region) in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat.
methodsPsychologically healthy young adults delivered a speech and performed mental arithmetic in one of three conditions: a) an evaluative audience condition that gave disapproving and negative nonverbal social signals (n = 59); b) an evaluative audience condition that provided supportive social signals (n = 60); or c) a no audience condition (n = 65). Heart rate (HR) and systolic and diastolic blood pressures (DBP) were measured before, during, and after the stress tasks to assess cardiovascular reactivity and recovery.
resultsIn the negative audience condition, there was a significant association between the 5-HTTLPR and systolic blood pressure, DBP, and HR reactivity. Individuals with the short/short genotype showed the greatest reactivity. The DBP and HR reactivity of short/short individuals in the negative audience condition was also greater than that of individuals with the short/short genotype in the no audience condition. These associations of the 5-HTLPR with HR reactivity were moderated by gender, being limited to females. With respect to cardiovascular recovery, short/short individuals in the negative audience condition exhibited impaired DBP recovery relative to other genotypes in the same condition, as well as short/short individuals in the no audience condition.
conclusionsThe 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes.
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