ArticleGenes & development2011
Synthetic circuit identifies subpopulations with sustained memory of DNA damage.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Review
- Simulating Genetic Circuits in Bacterial Populations with Growth Heterogeneity.Biophysical journal · 2018Article
- Molecular recordings by directed CRISPR spacer acquisition.Science (New York, N.Y.) · 2016Article
- Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells.ACS synthetic biology · 2016Article
- Mechanistic links between cellular trade-offs, gene expression, and growth.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Synthetic analog and digital circuits for cellular computation and memory.Current opinion in biotechnology · 2014Review
- Bacterial growth: global effects on gene expression, growth feedback and proteome partition.Current opinion in biotechnology · 2014Review
- Article
- Building synthetic memory.Current biology : CB · 2013Review
- Article
- Synthetic memory circuits for tracking human cell fate.Genes & development · 2012Article
- Contextualizing context for synthetic biology--identifying causes of failure of synthetic biological systems.Biotechnology journal · 2012Review
- Synthetic biology: advancing biological frontiers by building synthetic systems.Genome biology · 2012Review
- Pamela Silver: synthesizing a new biology. Interview by Caitlin Sedwick.The Journal of cell biology · 2012Article
- Synthetic biology: integrated gene circuits.Science (New York, N.Y.) · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopulations with heritable damage responses. Strongly responsive cells show multigenerational effects, including growth defects and iron-associated gene expression. Less-responsive cells exhibit increased mutation frequencies but resume wild-type behavior. These two subpopulations remain distinct for multiple generations, indicating a transmissible memory of damage. Collectively, this work demonstrates the efficacy of using synthetic biology to define how environmental exposure contributes to distinct cell fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.