PI3K p110β: more tightly controlled or constitutively active?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Idelalisib activates AKT via increased recruitment of PI3Kδ/PI3Kβ to BCR signalosome while reducing PDK1 in post-therapy CLL cells.Leukemia · 2022
   Article
2. PI3Kβ-A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling.Endocrinology · 2019
   Review
3. PI3King the right partner: unique interactions and signaling by p110β.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2015
   Article
4. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Nature reviews. Cancer · 2015
   Review
5. Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design.Protein science : a publication of the Protein Society · 2014
   Article
6. PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.Proceedings of the National Academy of Sciences of the United States of America · 2014
   Article
7. PI-3 kinase p110β: a therapeutic target in advanced prostate cancers.American journal of clinical and experimental urology · 2014
   Review
8. Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.PloS one · 2013
   Article
9. Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).Advances in biological regulation · 2013
   Article
10. Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.FEBS letters · 2012
    Review
11. The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Genes & development · 2012
    Article

Corrections and comments

• Comment on
  Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.2011

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.