Evidence map›Paper›PMID 21362517›Full record

ReviewSeminars in oncology2011

Positron emission tomography imaging of cancer biology: current status and future prospects.

Kai Chen, Xiaoyuan Chen

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Seminars in oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04626206 (Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626206 unknown statusnot on this mapstarted 2020, after this paper: background citation

Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases

TypeobservationalSponsorRoyal Marsden NHS Foundation TrustRan2020 to 2021Enrolled12ConditionsBrain Metastases, Adult
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Diagnostic value of [18F] FDG-PET and PET/CT in urinary bladder cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  3. Theranostics in nuclear medicine: the era of precision oncology.Medical oncology (Northwood, London, England) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. A newAmino acids · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Cancer cell metabolic plasticity in migration and metastasis.Clinical & experimental metastasis · 2021
    Review
  15. Synthesis, Radiolabeling, and Biological Evaluation of theACS pharmacology & translational science · 2021
    Article
  16. Application-specific nuclear medicalPhysics in medicine and biology · 2021
    Review
  17. Exploring Solvent Effects in the Radiosynthesis ofACS pharmacology & translational science · 2021
    Article
  18. Article
  19. Short 2-[Frontiers in medicine · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kai ChenMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. chenkai@usc.edu
Xiaoyuan Chen
Imaging Center · USNational Institute of Biomedical Imaging and Bioengineering · US

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000073
6 · The paper itself

Abstract

Positron emission tomography (PET) is one of the most rapidly growing areas of medical imaging, with many applications in the clinical management of patients with cancer. The principal goal of PET imaging is to visualize, characterize, and measure biological processes at the cellular, subcellular, and molecular levels in living subjects using noninvasive procedures. PET imaging takes advantage of the traditional diagnostic imaging techniques and introduces positron-emitting probes to determine the expression of indicative molecular targets at different stages of cancer progression. Although [(18)F]fluorodeoxyglucose ([(18)F]FDG)-PET has been widely utilized for staging and restaging of cancer, evaluation of response to treatment, differentiation of post-therapy alterations from residual or recurrent tumor, and assessment of prognosis, [(18)F]FDG is not a target-specific PET tracer. Over the last decade, numerous target-specific PET tracers have been developed and evaluated in preclinical and clinical studies. This review provides an overview of the current status and trends in the development of non-[(18)F]FDG PET probes in oncology and their application in the investigation of cancer biology.

Indexed as

Molecular ProbesApoptosisCell HypoxiaCell ProliferationErbB ReceptorsHumansMolecular ImagingNeoplasmsNeovascularization, PathologicPositron-Emission TomographyReceptors, SomatostatinErbB ReceptorsMolecular ProbesReceptors, Somatostatin

Identifiers

PMID21362517
PMCPMC3060704
OpenAlexW1981755022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.