Evidence map›Paper›PMID 21362515›Full record

ReviewSeminars in oncology2011

Molecular magnetic resonance contrast agents for the detection of cancer: past and present.

Alexei Bogdanov, Mary L Mazzanti

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Nanotechnology for cancer treatment.Nanotechnology reviews · 2015
    Article
  12. Review
  13. Molecular imaging probe development: a chemistry perspective.American journal of nuclear medicine and molecular imaging · 2012
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexei BogdanovDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Alexei.Bogdanov@umassmed.edu
Mary L Mazzanti
University of Massachusetts Chan Medical School · US

Funding

MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGINGR01EB000858 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2003 to 2022
$6.0M
Molecular Imaging Probes for Reporting on Vascular Oxidative ResponseR01AG034901 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2010 to 2013
$1.3M
Transcription Factor Reporter TechnologyR33CA134385 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2008 to 2010
$938k
Molecular Imaging to Determine the Risk of Rupture of Cerebral AneurysmsR21NS061132 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2008 to 2009
$400k
NCI NIH HHS R33 CA134385NIA NIH HHS R01 AG034901NIBIB NIH HHS R01 EB000858NINDS NIH HHS R21 NS061132
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) is a powerful diagnostic tool with unsurpassed spatial resolution that is capable of providing detailed information about the structure and composition of tumors. The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes. Current efforts are directed at enhancing the capabilities of MRI in oncology by adding contrast agents with molecular specificities to the growing armamentarium of diagnostic probes that produce signal by changing local proton relaxation times as a consequence of specific contrast agent binding to cell surface receptors or extracellular matrix components. We review herein the most notable examples, illustrating major trends in the development of specific probes for high-resolution imaging in molecular oncology.

Indexed as

Contrast MediaMolecular ProbesHumansMagnetic Resonance ImagingMolecular ImagingNeoplasmsContrast MediaMolecular Probes

Identifiers

PMID21362515
PMCPMC3080112
OpenAlexW2089934112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.