ArticleTraffic (Copenhagen, Denmark)2011
Clathrin heavy chain gene fusions expressed in human cancers: analysis of cellular functions.
Article in Traffic (Copenhagen, Denmark), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Clathrin heavy chain phosphorylated at T606 plays a role in proper cell division.Cell cycle (Georgetown, Tex.) · 2019Article
- Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein.BMC bioinformatics · 2017Article
- Unraveling protein-protein interactions in clathrin assemblies via atomic force spectroscopy.Methods (San Diego, Calif.) · 2013Article
- Nuclear localization of clathrin involves a labile helix outside the trimerization domain.FEBS letters · 2013Article
- Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma.World journal of gastroenterology · 2012Article
- The role of clathrin in mitotic spindle organisation.Journal of cell science · 2012Review
- Mitotic moonlighting functions for membrane trafficking proteins.Traffic (Copenhagen, Denmark) · 2011Review
- Pulling it together: The mitotic function of TACC3.Bioarchitecture · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Clathrin is a protein expressed ubiquitously that has important functions in membrane trafficking and mitosis. Two different gene fusions involving clathrin heavy chain (CHC) have been described in human cancers. These involve either anaplastic lymphoma kinase (ALK) or transcription factor binding to IGHM enhancer 3 (TFE3) and raise the possibility that altered clathrin function in cells expressing the fusion proteins could contribute to oncogenesis. In the present study, we tested the functions of CHC-ALK and CHC-TFE3 in endocytosis and mitosis. CHC-ALK is comparable to full-length CHC in both functions indicating that malignant transformation in cells expressing CHC-ALK is not because of any change in clathrin function. CHC-TFE3 is not functional in endocytosis, but can substitute for CHC in mitosis. CHC-TFE3 causes prolonged interphase that is attributed to the TFE3 portion of the protein. We also describe how CHC-TFE3 is a dimer. This suggests that clathrin's proposed role in intermicrotubule bridging can be fulfilled not only by trimers but also by dimers. Finally, this study shows that the membrane trafficking and mitotic functions of clathrin are independent and separable.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.