ArticleJournal of biomedical optics2011
3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- A Lightweight, 3D-Printable, Low-Cost, "One-Click" Dorsal Skin Window for High-Quality Long-Term Multimodal Subcutaneous Tumor Imaging.Advanced healthcare materials · 2026Article
- An Automatic Unmixing Approach to Detect Tissue Chromophores from Multispectral Photoacoustic Imaging.Sensors (Basel, Switzerland) · 2020Article
- Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system.Photoacoustics · 2019Article
- State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics.Contrast media & molecular imaging · 2019Review
- Review of Photoacoustic Imaging for Imaging-Guided Spinal Surgery.Neurospine · 2018Article
- Rapid scanning wide-field clutter elimination in epi-optoacoustic imaging using comb LOVIT.Photoacoustics · 2018Article
- Laser scanning laser diode photoacoustic microscopy system.Photoacoustics · 2018Article
- Quantitative comparison of PZT and CMUT probes for photoacoustic imaging: Experimental validation.Photoacoustics · 2017Article
- In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion).Biomedical optics express · 2016Article
- Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience.Radiology · 2016Review
- Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization.Theranostics · 2016Article
- A high-affinity, high-stability photoacoustic agent for imaging gastrin-releasing peptide receptor in prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Light in and sound out: emerging translational strategies for photoacoustic imaging.Cancer research · 2014Review
- Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT).Photoacoustics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the tumor microenvironment is critical to characterizing how cancers operate and predicting their response to treatment. We describe a novel, high-resolution coregistered photoacoustic (PA) and pulse echo (PE) ultrasound system used to image the tumor microenvironment. Compared to traditional optical systems, the platform provides complementary contrast and important depth information. Three mice are implanted with a dorsal skin flap window chamber and injected with PC-3 prostate tumor cells transfected with green fluorescent protein. The ensuing tumor invasion is mapped during three weeks or more using simultaneous PA and PE imaging at 25 MHz, combined with optical and fluorescent techniques. Pulse echo imaging provides details of tumor structure and the surrounding environment with 100-μm(3) resolution. Tumor size increases dramatically with an average volumetric growth rate of 5.35 mm(3)/day, correlating well with 2-D fluorescent imaging (R = 0.97, p < 0.01). Photoacoustic imaging is able to track the underlying vascular network and identify hemorrhaging, while PA spectroscopy helps classify blood vessels according to their optical absorption spectrum, suggesting variation in blood oxygen saturation. Photoacoustic and PE imaging are safe, translational modalities that provide enhanced depth resolution and complementary contrast to track the tumor microenvironment, evaluate new cancer therapies, and develop molecular contrast agents in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.