ArticleJournal of biomedical optics2011
Picosecond spectral coherent anti-Stokes Raman scattering imaging with principal component analysis of meibomian glands.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model.International journal of molecular sciences · 2019Pooled it
- Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on Raman spectroscopy.Frontiers in medicine · 2025Article
- Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.International journal of molecular sciences · 2023Article
- Coherent Raman scattering microscopy: capable solution in search of a larger audience.Journal of biomedical optics · 2021Article
- Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue.Scientific reports · 2021Article
- Meibomian Gland Dysfunction: What Have Animal Models Taught Us?International journal of molecular sciences · 2020Review
- Mammalian cell and tissue imaging using Raman and coherent Raman microscopy.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Eicosapentaenoic acid (EPA) activates PPARγ signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC).The ocular surface · 2020Article
- Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy.The ocular surface · 2019Review
- High-resolution infrared imaging of biological samples with third-order sum-frequency generation microscopy.Biomedical optics express · 2018Article
- Meibocyte differentiation and renewal: Insights into novel mechanisms of meibomian gland dysfunction (MGD).Experimental eye research · 2017Review
- Hyperspectral imaging with laser-scanning sum-frequency generation microscopy.Biomedical optics express · 2017Article
- A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum.Journal of Raman spectroscopy : JRS · 2017Article
- Evaporation and Hydrocarbon Chain Conformation of Surface Lipid Films.The ocular surface · 2016Article
- PPARγ Regulates Mouse Meibocyte Differentiation and Lipid Synthesis.The ocular surface · 2016Article
- In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
- Meibomian gland dysfunction: hyperkeratinization or atrophy?BMC ophthalmology · 2015Review
- Spectrometer-free vibrational imaging by retrieving stimulated Raman signal from highly scattered photons.Science advances · 2015Article
- Denoising Stimulated Raman Spectroscopic Images by Total Variation Minimization.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- Fast vibrational imaging of single cells and tissues by stimulated Raman scattering microscopy.Accounts of chemical research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The lipid distribution in the mouse meibomian gland was examined with picosecond spectral anti-Stokes Raman scattering (CARS) imaging. Spectral CARS data sets were generated by imaging specific localized regions of the gland within tissue sections at consecutive Raman shifts in the CH(2) stretching vibrational range. Spectral differences between the location specific CARS spectra obtained in the lipid-rich regions of the acinus and the central duct were observed, which were confirmed with a Raman microspectroscopic analysis, and attributed to meibum lipid modifications within the gland. A principal component analysis of the spectral data set reveals changes in the CARS spectrum when transitioning from the acini to the central duct. These results demonstrate the utility of picosecond spectral CARS imaging combined with multivariate analysis for assessing differences in the distribution and composition of lipids in tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.