Evidence map›Paper›PMID 21360754›Full record

Trial reportInternational journal of geriatric psychiatry2011

Depression symptom ratings in geriatric patients with bipolar mania.

Martha Sajatovic, Rayan Al Jurdi, Ariel Gildengers, Rebecca L Greenberg, Thomas Tenhave, Martha L Bruce, Benoit Mulsant, Robert C Young

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of geriatric psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00254488 (Acute Pharmacotherapy of Late-Life Mania), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00254488 phase4completednot on this map

Acute Pharmacotherapy of Late-Life Mania (GERI-BD)

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2005 to 2011Enrolled224ConditionsBipolar Disorder, ManiaArmsLithium (LI), Divalproex (DV)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Martha SajatovicDepartment of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA. martha.sajatovic@uhhospitals.org
Rayan Al Jurdi
Ariel Gildengers
Rebecca L Greenberg
Thomas Tenhave
Martha L Bruce
Benoit Mulsant
Robert C Young
Cornell University · USMichael E. DeBakey VA Medical Center · USUniversity Hospitals Case Medical Center · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USUniversity of Toronto · CA

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DAVIS, PAMELA B · 1985 to 2007
$22.2M
Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
Acute Pharmacotherapy of Late-Life ManiaU01MH074091 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI SAJATOVIC, MARTHA X · 2005 to 2009
$1.2M
NCATS NIH HHS UL1 TR000005NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR00080NCRR NIH HHS UL1 RR024989NIMH NIH HHS K02 MH067028NIMH NIH HHS U01 MH074091
6 · The paper itself

Abstract

objectiveGiven the paucity of information available regarding standardized ratings of depression symptoms in bipolar manic states, and in particular those in older adults, we explored depression ratings in symptomatic participants in a multicenter study of treatment of bipolar I disorder in late life.

methodsBaseline data was obtained from the first 100 patients enrolled in an NIMH-funded, 9-week, randomized, double-blind RCT comparing treatment with lithium or valproate in patients of age 60 years and older with Type I Bipolar mania or hypomania. This multi-site study was conducted at six academic medical centers in the United States and enrolled inpatients and outpatients with a total Young Mania Rating Scale (YMRS) score of 18 or greater. Depressive symptoms were evaluated with the Hamilton Depression Rating Scale (HAM-D) and the Montgomery-Asberg Depression Rating Scale (MADRS). The criterion for at least moderate bipolar depressive symptoms was the European College of Neuropsychopharmacology (ECNP) Consensus Meeting definition of HAM-D 17 total score >20.

resultsEleven percent of patients had mixed symptoms defined by depression scale severity according to ECNP criterion. In the overall sample, total scores on the two depression scales were highly correlated. Total YMRS scores of this mixed symptom group were similar to the remainder of the sample.

conclusionsThese preliminary findings suggest that moderate to severe depressive symptoms occur in about one in ten bipolar manic elders. Future studies are needed to further evaluate symptom profiles, clinical correlates, and treatments for bipolar older adults with combined manic and depressive symptoms.

Indexed as

AgedAged, 80 and overAntimanic AgentsBipolar DisorderDepressive DisorderDouble-Blind MethodFemaleGeriatric PsychiatryHumansLithiumMaleMiddle AgedPsychiatric Status Rating ScalesRegression AnalysisUnited StatesValproic AcidAntimanic AgentsLithiumValproic Acid

Identifiers

PMID21360754
PMCPMC3651791
OpenAlexW2098667720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.