ArticleArthritis and rheumatism2011
Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.
Article in Arthritis and rheumatism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Pregnancy and the Autoimmune Patient.Current allergy and asthma reports · 2024Review
- Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation.Blood advances · 2023Article
- Fetal-placental antigens and the maternal immune system: Reproductive immunology comes of age.Immunological reviews · 2022Review
- Endoplasmic Reticulum Stress, Oxidative Stress, and Rheumatic Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?Frontiers in medicine · 2022Review
- Disease progression in relation to pre-onset parity among women with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2020Article
- Nonendocrine mechanisms of sex bias in rheumatic diseases.Nature reviews. Rheumatology · 2019Review
- Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.Frontiers in immunology · 2019Review
- Specific Donor HLA-DR Types Correlate With Altered Susceptibility to Development of Chronic Lung Allograft Dysfunction.Transplantation · 2018Article
- Unravelling the biological secrets of microchimerism by single-cell analysis.Briefings in functional genomics · 2018Article
- Review
- Increased risk of rheumatoid arthritis among mothers with children who carryAnnals of the rheumatic diseases · 2017Article
- Rheumatoid arthritis: Forward and reverse inheritance - the yin and the yang.Nature reviews. Rheumatology · 2017Article
- Juvenile idiopathic arthritis in relation to perinatal and maternal characteristics: a case control study.Pediatric rheumatology online journal · 2017Article
- Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.Seminars in immunopathology · 2016Review
- Strategies and methods to study female-specific cardiovascular health and disease: a guide for clinical scientists.Biology of sex differences · 2016Review
- Adverse pregnancy outcomes and risk of subsequent rheumatoid arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveHLA-DRB1 alleles associated with risk of rheumatoid arthritis (RA) encode similar HLA-DRB1 sequences, called the shared epitope (SE). The most common SE sequences are QKRAA and QRRAA. Nevertheless, a substantial number of RA patients lack the SE. Bidirectional fetal-maternal trafficking results in long-term persistence of fetal cells in the mother and maternal cells in her offspring, a process known as microchimerism. This study was undertaken to discover whether RA patients who lack the SE can acquire it through microchimerism.
methodsWe studied a total of 86 female subjects who were genotypically negative for the SE, comprising 52 patients with RA and 34 healthy controls. We developed specific real-time quantitative polymerase chain reaction assays for the SE-encoded sequences QKRAA and QRRAA, and used them to test DNA extracted from peripheral blood mononuclear cells.
resultsMicrochimerism with the SE was found significantly more often in RA patients than controls (odds ratio 4.1 [95% confidence interval 1.6-10.0], P = 0.003). Concentrations of SE microchimerism were also significantly higher among RA patients than controls (P = 0.002). In separate analyses for SE type, the prevalence of QKRAA microchimerism in RA patients versus healthy controls was 17% versus 3% (9 of 52 versus 1 of 34; P = 0.03) and the prevalence of QRRAA microchimerism was 40% versus 18% (21 of 52 versus 6 of 34; P = 0.04), respectively. Microchimerism concentrations were also higher in RA patients than healthy subjects for QKRAA (P = 0.03) and QRRAA (P = 0.03).
conclusionThese results indicate that RA patients who genotypically lack the SE can acquire the SE as persistent microchimerism from fetal-maternal cell exchange, suggesting that SE-encoding microchimerism could be a risk factor for RA.
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