ArticleJournal of nephrology
LDL particle size and number compared with LDL cholesterol and risk categorization in end-stage renal disease patients.
Article in Journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Estimated small dense low-density lipoprotein cholesterol and nonalcoholic fatty liver disease in nonobese populations.Journal of diabetes investigation · 2024Article
- A network analysis of depressive symptoms and metabolomics.Psychological medicine · 2023Article
- Low-density lipoprotein cholesterol to apolipoprotein B ratio predicts mortality and cardiovascular events in peritoneal dialysis patients.International urology and nephrology · 2023Article
- Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients.Clinical kidney journal · 2021Article
- Proinflammatory and Hyperinsulinemic Dietary Patterns Are Associated With Specific Profiles of Biomarkers Predictive of Chronic Inflammation, Glucose-Insulin Dysregulation, and Dyslipidemia in Postmenopausal Women.Frontiers in nutrition · 2021Article
- Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Article
- Lipoprotein subfractions and particle size in end-stage renal disease.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundFew studies have been conducted that make comparisons between traditional measures of cholesterol and cholesterol subfractions, and only one study has compared low-density lipoprotein cholesterol (LDL-C) particle number, LDL-C particle size and LDL-C among end-stage renal disease (ESRD) patients. The purpose of this study was to examine the relationships between cholesterol measures and differences in risk stratification when using ATP-III guidelines compared with cholesterol particle number and size in ESRD patients.
methodsESRD patients (n=1,092) from clinics associated with the Central Texas Nephrology Associates were recruited to participate in this study.
resultsLDL particle size categorized more patients at-risk when compared with LDL-C, non-HDL-C and triglycerides. Pearson correlation coefficients revealed a strong significant correlation between LDL-C and LDL particle number (r2=0.908, p=0.0001) and a significant correlation between LDL particle number and LDL particle size (r2=-0.290, p=0.0001). A significant but weak correlation existed between LDL-C and LDL particle size (r2=0.107, p=0.0001). A significant correlation existed between LDL particle number and triglycerides (r2=0.335, p=0.0001) and a significant inverse relationship between LDL particle size and triglycerides (r2=-0.500, p=0.0001).
conclusionsOur study seems to suggest that using LDL particle size may help to identify those who would not be considered at-risk using LDL-C, non-HDL-C or triglycerides alone, and can be used as a further screening measure that may be more predictive of coronary heart disease outcomes.
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