Trial reportChild neuropsychology : a journal on normal and abnormal development in childhood and adolescence2011
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.
Trial report in Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.PloS one · 2021Pooled it
- Anemia and Red Blood Cell Transfusions, Cerebral Oxygenation, Brain Injury and Development, and Neurodevelopmental Outcome in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis.BMJ (Clinical research ed.) · 2015Pooled it
- A new perspective on best transfusion practices.Blood transfusion = Trasfusione del sangue · 2013Guideline
- Enteral Iron Supplementation in Infants Born Extremely Preterm and its Positive Correlation with Neurodevelopment; Post Hoc Analysis of the Preterm Erythropoietin Neuroprotection Trial Randomized Controlled Trial.The Journal of pediatrics · 2021Trial
- Long-term outcome of brain structure in female preterm infants: possible associations of liberal versus restrictive red blood cell transfusions.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2021Trial
- Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo.Pediatrics · 2014Trial
- A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants.Pediatrics · 2013Trial
- A randomized, masked study of weekly erythropoietin dosing in preterm infants.The Journal of pediatrics · 2012Trial
- Neonatal phlebotomy-induced anemia compromises mitochondrial bioenergetics in the developing hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Biological sex and transfusion practices in the NICU.Pediatric research · 2025Article
- The transfusion of prematures early school age follow-up (TOP 5): protocol for a longitudinal cohort study.BMC pediatrics · 2025Article
- Sex differences in the association of pretransfusion haemoglobin and cognition in preterm infants.BMJ paediatrics open · 2024Observational
- Blood Product Transfusions for Children in the Perioperative Period and for Critically Ill Children.Deutsches Arzteblatt international · 2024Review
- Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023Review
- Dose- and sex-dependent effects of phlebotomy-induced anemia on the neonatal mouse hippocampal transcriptome.Pediatric research · 2022Article
- Two-year neurodevelopmental outcomes of preterm infants who received red blood cell transfusion.Blood transfusion = Trasfusione del sangue · 2022Article
- Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant.The Journal of pediatrics · 2022Article
- Sex-specific cytokine responses and neurocognitive outcome after blood transfusions in preterm infants.Pediatric research · 2022Article
- Thresholds for blood transfusion in extremely preterm infants: A review of the latest evidence from two large clinical trials.Frontiers in pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivePreterm infants are frequently transfused with red blood cells based on standardized guidelines or clinical concerns that anemia taxes infants' physiological compensatory mechanisms and thereby threatens their health and well-being. The impact of various transfusion guidelines on long-term neurocognitive outcome is not known. The purpose of this study is to evaluate long-term neurocognitive outcome on children born prematurely and treated at birth with different transfusion guidelines.
methodsNeurocognitive outcomes were examined at school age for 56 preterm infants randomly assigned to a liberal (n = 33) or restrictive (n = 23) transfusion strategy. Tests of intelligence, achievement, language, visual-spatial/motor, and memory skills were administered. Between-group differences were assessed.
resultsThose in the liberal transfusion group performed more poorly than those in the restrictive group on measures of associative verbal fluency, visual memory, and reading.
conclusionsFindings highlight possible long-term neurodevelopmental consequences of maintaining higher hematocrit levels.
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