ArticlePediatric cardiology2011
Cardiomyopathy of Friedreich's ataxia: use of mouse models to understand human disease and guide therapeutic development.
Article in Pediatric cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Cardiovascular Research in Friedreich Ataxia: Unmet Needs and Opportunities.JACC. Basic to translational science · 2022Review
- Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia.Heliyon · 2022Article
- Neuro-Cardio Mechanisms in Huntington's Disease and Other Neurodegenerative Disorders.Frontiers in physiology · 2018Review
- Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in aFrontiers in molecular neuroscience · 2018Article
- [Heart involvement in Friedreich's ataxia].Herz · 2015Review
- High-throughput immunoassay for the biochemical diagnosis of Friedreich ataxia in dried blood spots and whole blood.Clinical chemistry · 2013Article
- Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Molecular and cellular neurosciences · 2013Review
- Friedreich ataxia: neuropathology revised.Journal of neuropathology and experimental neurology · 2013Review
- Relation of cytosolic iron excess to cardiomyopathy of Friedreich's ataxia.The American journal of cardiology · 2012Article
- Cardiomyopathy of Friedreich's ataxia (FRDA).Irish journal of medical science · 2012Article
- Clinical features of Friedreich ataxia.Journal of child neurology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Friedreich's ataxia is a multisystem disorder of mitochondrial function affecting primarily the heart and brain. Patients experience a severe cardiomyopathy that can progress to heart failure and death. Although the gene defect is known, the precise function of the deficient mitochondrial protein, frataxin, is not known and limits therapeutic development. Animal models have been valuable for understanding the basic events of this disease. A significant need exists to focus greater attention on the heart disease in Friedreich's ataxia, to understand its long-term outcome, and to develop new therapeutic strategies using existing medications and approaches. This review discusses some key features of the cardiomyopathy in Friedreich's ataxia and potential therapeutic developments.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.